EB 病毒相关疾病中的组蛋白甲基化。
Histone methylation in Epstein-Barr virus-associated diseases.
机构信息
Beijing Key Laboratory of Pediatric Respiratory Infectious Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Research Unit of Critical Infection in Children, 2019RU016, Chinese Academy of Medical Sciences, Beijing, 100045, China.
出版信息
Epigenomics. 2024;16(11-12):865-877. doi: 10.1080/17501911.2024.2345040. Epub 2024 May 10.
Epstein-Barr virus (EBV) infection is linked to various human diseases, including both noncancerous conditions like infectious mononucleosis and cancerous diseases such as lymphoma and nasopharyngeal carcinoma. After the initial infection, EBV establishes a lifelong presence and remains latent in specific cells. This latent infection causes changes in the epigenetic marks known as histone methylation. Many studies have examined the role of histone methylation in different EBV-associated diseases, and understanding how EBV affects histone methylation can help us identify potential targets for epigenetic therapies. This review focuses on the research progress made in understanding histone methylation in well-studied EBV-associated diseases, intending to provide insights into potential strategies based on histone methylation to combat EBV-related ailments.
爱泼斯坦-巴尔病毒（EBV）感染与多种人类疾病有关，包括传染性单核细胞增多症等非癌性疾病和淋巴瘤、鼻咽癌等癌性疾病。初次感染后，EBV 会建立终身存在并潜伏在特定细胞中。这种潜伏感染会导致表观遗传标记（如组蛋白甲基化）发生变化。许多研究已经探讨了组蛋白甲基化在不同 EBV 相关疾病中的作用，了解 EBV 如何影响组蛋白甲基化有助于我们确定潜在的表观遗传治疗靶点。本综述重点介绍了在理解 EBV 相关疾病中组蛋白甲基化方面取得的研究进展，旨在为基于组蛋白甲基化的对抗 EBV 相关疾病的潜在策略提供思路。
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