双膦酸盐相关颌骨坏死患者的治疗结果：一项前瞻性研究。
Treatment outcomes in patients with bisphosphonate-related osteonecrosis of the jaws: a prospective study.
作者信息
Scoletta Matteo, Arduino Paolo G, Dalmasso Paola, Broccoletti Roberto, Mozzati Marco
机构信息
Oral Surgery Unit, Dentistry Section, Department of Clinical Physiopathology, University of Turin, Turin, Italy.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Jul;110(1):46-53. doi: 10.1016/j.tripleo.2010.02.020. Epub 2010 May 10.
OBJECTIVES
The aim of this study was to evaluate the 2-year success rate of management of patients with bisphosphonate-related osteonecrosis of the jaws (BRONJ).
STUDY DESIGN
A prospective study was performed. Positive outcome variables were the resolution of symptoms and the status of the mucosa.
RESULTS
A total of 37 patients are described. The precipitating event was a dental extraction in 22 cases (59.5%). Thirteen patients (35.1%) underwent surgery, and 24 (64.9%) underwent antimicrobial therapy alone. After 2 years, 20 patients (54.1%) presented with soft tissue closure over previously exposed bone, and there were no statistical differences in gender, age, bisphosphonate treatment, or treatment modalities. Spontaneous lesions seemed to have a worse prognosis (P = .001).
CONCLUSIONS
Initial antimicrobial treatment, and later surgery for unresponsive patients, might be a feasible treatment modality for BRONJ. Because these results are not conclusive, it would be very interesting to know if this statement would be the same with a greater number of patients.
目的
本研究旨在评估双膦酸盐相关颌骨坏死（BRONJ）患者治疗的2年成功率。
研究设计
进行了一项前瞻性研究。阳性结果变量为症状的缓解和黏膜状况。
结果
共描述了37例患者。诱发事件为拔牙22例（59.5%）。13例患者（35.1%）接受了手术，24例（64.9%）仅接受了抗菌治疗。2年后，20例患者（54.1%）在先前暴露的骨上实现了软组织闭合，在性别、年龄、双膦酸盐治疗或治疗方式方面无统计学差异。自发病变似乎预后较差（P = 0.001）。
结论
初始抗菌治疗，以及后期对无反应患者进行手术，可能是BRONJ的一种可行治疗方式。由于这些结果尚无定论，了解在更多患者中该说法是否相同将非常有趣。
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