Laboratory of Bacterial Pathogenesis, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.
Int J Med Microbiol. 2010 Aug;300(6):357-62. doi: 10.1016/j.ijmm.2010.04.002. Epub 2010 May 10.
Endolysins (or lysins) are highly evolved enzymes produced by bacteriophage (phage for short) to digest the bacterial cell wall for phage progeny release. In Gram-positive bacteria, small quantities of purified recombinant lysin added externally results in immediate lysis causing log-fold death of the target bacterium. Lysins have been used successfully in a variety of animal models to control pathogenic antibiotic-resistant bacteria found on mucosal surfaces and infected tissues. Their specificity for the pathogen without disturbing the normal flora, the low chance of bacterial resistance, and their ability to kill colonizing pathogens on mucosal surfaces, a capacity previously unavailable, make them ideal anti-infectives in an age of mounting resistance. Here we review the current literature showing the effectiveness of these enzymes in controlling a variety of infections.
溶菌素（或裂解酶）是噬菌体产生的高度进化的酶，用于消化细菌细胞壁以释放噬菌体后代。在革兰氏阳性菌中，少量纯化的重组溶菌素添加到外部会立即导致细胞裂解，导致目标细菌对数级死亡。溶菌素已成功用于多种动物模型，以控制在粘膜表面和感染组织上发现的致病性抗生素耐药菌。它们对病原体的特异性而不干扰正常菌群，细菌耐药的可能性低，以及它们在粘膜表面杀死定植病原体的能力，这是以前无法实现的，使它们成为耐药时代的理想抗感染药物。在这里，我们回顾了目前的文献，这些文献表明这些酶在控制各种感染方面的有效性。
