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CRM（197）结合疫苗用于儿科的开发和使用概述。

Overview of the development and current use of CRM(197) conjugate vaccines for pediatric use.

出版信息

Vaccine. 2010 Jun 17;28(27):4335-9. doi: 10.1016/j.vaccine.2010.04.072. Epub 2010 May 7.

DOI:10.1016/j.vaccine.2010.04.072
PMID:20452430
Abstract

Glycoconjugate vaccines have been proven safe and effective against various diseases in children. Although these vaccines have a history of effectiveness, there are still many unanswered questions to be addressed, including conjugate interference when multiple vaccines are administered at one time, expansion of serotype coverage, effectiveness in special populations, and issues relating to conjugate vaccine use in the developing world. This paper focuses on the use of CRM(197) as a carrier protein, contrasting it to other carrier proteins used in single-antigen pediatric vaccines as well as identifying areas for future study.

摘要

糖缀合物疫苗已被证明在预防儿童的各种疾病方面是安全且有效的。虽然这些疫苗具有良好的效果记录，但仍有许多悬而未决的问题需要解决，包括同时接种多种疫苗时的结合物干扰、血清型覆盖范围的扩大、在特殊人群中的效果以及与发展中国家使用结合疫苗有关的问题。本文重点介绍 CRM(197)作为载体蛋白的使用情况，将其与用于单抗原儿科疫苗的其他载体蛋白进行对比，并确定未来的研究领域。

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