Department of Speech-Language Pathology, University of Toronto, Toronto, Ontario, Canada.
Neuroimage. 2010 Oct 1;52(4):1645-53. doi: 10.1016/j.neuroimage.2010.04.277. Epub 2010 May 7.
We used magnetoencephalography to investigate auditory evoked responses to speech vocalizations and non-speech tones in adults who do and do not stutter. Neuromagnetic field patterns were recorded as participants listened to a 1 kHz tone, playback of their own productions of the vowel /i/ and vowel-initial words, and actively generated the vowel /i/ and vowel-initial words. Activation of the auditory cortex at approximately 50 and 100 ms was observed during all tasks. A reduction in the peak amplitudes of the M50 and M100 components was observed during the active generation versus passive listening tasks dependent on the stimuli. Adults who stutter did not differ in the amount of speech-induced auditory suppression relative to fluent speakers. Adults who stutter had shorter M100 latencies for the actively generated speaking tasks in the right hemisphere relative to the left hemisphere but the fluent speakers showed similar latencies across hemispheres. During passive listening tasks, adults who stutter had longer M50 and M100 latencies than fluent speakers. The results suggest that there are timing, rather than amplitude, differences in auditory processing during speech in adults who stutter and are discussed in relation to hypotheses of auditory-motor integration breakdown in stuttering.
我们使用脑磁图研究了不口吃和口吃的成年人对言语发声和非言语音的听觉诱发反应。当参与者听 1 kHz 音调、回放他们自己的/i/元音和元音起始词的发音以及主动生成/i/元音和元音起始词时，记录了神经磁场模式。在所有任务中都观察到了大约 50 和 100 毫秒时听觉皮层的激活。在主动生成与被动聆听任务中，根据刺激的不同，观察到 M50 和 M100 成分的峰值振幅减小。与流利的说话者相比，口吃的成年人在言语引起的听觉抑制量方面没有差异。口吃的成年人在右半球主动生成说话任务中的 M100 潜伏期比左半球短，但流利的说话者在两个半球的潜伏期相似。在被动聆听任务中，口吃的成年人的 M50 和 M100 潜伏期比流利的说话者长。结果表明，口吃者在言语过程中的听觉处理存在时间而非幅度差异，并与口吃的听觉-运动整合中断假说相关讨论。
