Department of Rheumatology, Zhongshan Hospital, Fudan University, no. 180, Road Fenglin, Shanghai 200032, China.
Joint Bone Spine. 2010 Dec;77(6):608-10. doi: 10.1016/j.jbspin.2010.02.012. Epub 2010 May 8.
Hypoparathyroidism is rare in patients with systemic lupus erythematosus (SLE). Here we describe a case of SLE coexisted with hypoparathyroidism and ankylosing spondylitis with definite diagnosis, and also give a review of past five cases of SLE with hypoparathyroidism. We find that hypoparathyroidism is easily ignored by subtle manifestations despite of its significant complications. More attention should be paid to clues to hypocalcemia, symptoms of central nervous system and prolonged QT interval on electrocardiogram. The three diseases may be coexistent of genetically determined markers. The cause of hypoparathyroidism in SLE patient is not clear. It may be independent of SLE.
甲状旁腺功能减退症在系统性红斑狼疮（SLE）患者中较为罕见。本文描述了一例明确诊断的 SLE 合并甲状旁腺功能减退症和强直性脊柱炎病例，并对过去 5 例 SLE 合并甲状旁腺功能减退症病例进行了回顾。我们发现，尽管甲状旁腺功能减退症并发症显著，但由于其表现细微，容易被忽视。应更加注意低钙血症的线索、中枢神经系统症状和心电图上 QT 间期延长。这三种疾病可能与遗传决定的标记物同时存在。SLE 患者甲状旁腺功能减退症的病因尚不清楚，可能与 SLE 无关。
