Watts Gerald F, Chan Dick C
Lipid Disorders Clinic and Metabolic Research Centre, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia.
Atheroscler Suppl. 2010 Jun;11(1):61-4. doi: 10.1016/j.atherosclerosissup.2010.04.044. Epub 2010 May 10.
Dyslipidaemia is a common cardiovascular risk factor in insulin resistant subjects with obesity, type 2 diabetes mellitus and the metabolic syndrome. Lipoprotein metabolism is complex and abnormal plasma concentrations result from alterations in the rates of production and/or catabolism of diverse lipoprotein particles. Understanding the dysregulation and therapeutic correction of lipoprotein transport in insulin resistant states has relied on the use of stable isotope tracers and modelling methods. The effects of lifestyle and therapeutic interventions on the kinetics of apolipoproteins B-100 and A-I containing lipoproteins are reviewed.
血脂异常是肥胖、2型糖尿病和代谢综合征等胰岛素抵抗患者常见的心血管危险因素。脂蛋白代谢复杂，血浆浓度异常是由多种脂蛋白颗粒生成和/或分解代谢速率改变所致。了解胰岛素抵抗状态下脂蛋白转运的失调及治疗纠正依赖于使用稳定同位素示踪剂和建模方法。本文综述了生活方式和治疗干预对含载脂蛋白B-100和A-I的脂蛋白动力学的影响。
