College of Pharmacy, University of Georgia, 1200 Colliers Creek Road, Watkinsville, GA 30677, USA.
J Am Pharm Assoc (2003). 2010 May-Jun;50(3):e89-99; quiz e100-1. doi: 10.1331/JAPhA.2010.10028.
To review the assessment and recommended management of mild to moderate chronic pain in the older adult.
Medline search using the terms pain, older adult, and analgesics, current national guidelines, and authors' case experiences.
Assessing pain in cognitively intact and impaired older adults is essential to safe use of psychoactive medications. Following the guidelines of the American Geriatrics Society for persistent pain in the older adult provides guidance to the safe use of analgesics and other psychoactive drugs. Dosing of acetaminophen should be limited to avoid liver toxicity, and topical analgesics are preferred for focal pain. Full-dose nonsteroidal anti-inflammatory drugs should not be used for more than short periods, in order to avoid gastrointestinal, renal, and cardiovascular complications. Potentially inappropriate opioid analgesics and safer alternatives are encouraged. A description of other psychoactive medications for neuropathic pain and the role of vitamin D and depression in chronic pain is provided.
The assessment of pain and use of analgesics in the older adult should benefit and not increase drug-related morbidity and mortality.
回顾老年人轻度至中度慢性疼痛的评估和推荐管理方法。
使用术语“疼痛”、“老年人”和“镇痛药”,结合当前国家指南和作者的病例经验,在 Medline 上进行搜索。
评估认知功能正常和受损的老年患者的疼痛对于安全使用精神药物至关重要。遵循美国老年医学会关于老年人持续性疼痛的指南,为安全使用镇痛药和其他精神药物提供了指导。应限制对乙酰氨基酚的剂量以避免肝毒性,并且对于局部疼痛,应首选局部镇痛药。为避免胃肠道、肾脏和心血管并发症,不应长时间使用全剂量非甾体抗炎药。鼓励使用潜在不当的阿片类镇痛药和更安全的替代品。还描述了其他用于治疗神经病理性疼痛的精神药物以及维生素 D 和抑郁在慢性疼痛中的作用。
老年人疼痛的评估和镇痛药的使用应该受益,而不会增加与药物相关的发病率和死亡率。