Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Cold Spring Harb Perspect Biol. 2010 Apr;2(4):a000554. doi: 10.1101/cshperspect.a000554. Epub 2010 Feb 17.
A- and B-type lamins are the major intermediate filaments of the nucleus. Lamins engage in a plethora of stable and transient interactions, near the inner nuclear membrane and throughout the nucleus. Lamin-binding proteins serve an amazingly diverse range of functions. Numerous inner-membrane proteins help anchor lamin filaments to the nuclear envelope, serving as part of the nuclear "lamina" network that is essential for nuclear architecture and integrity. Certain lamin-binding proteins of the inner membrane bind partners in the outer membrane and mechanically link lamins to the cytoskeleton. Inside the nucleus, lamin-binding proteins appear to serve as the "adaptors" by which the lamina organizes chromatin, influences gene expression and epigenetic regulation, and modulates signaling pathways. Transient interactions of lamins with key components of the transcription and replication machinery may provide an additional level of regulation or support to these essential events.
A 型和 B 型核纤层蛋白是细胞核的主要中间丝。核纤层蛋白在核内膜附近和整个细胞核中发生大量稳定和瞬时的相互作用。核纤层结合蛋白具有惊人多样的功能。许多内膜蛋白有助于将核纤层丝锚定在核膜上，作为核“层网络”的一部分，对核结构和完整性至关重要。某些内膜的核纤层结合蛋白与外膜中的伴侣结合，并将核纤层机械地连接到细胞骨架上。在细胞核内，核纤层结合蛋白似乎充当“衔接子”，通过核纤层组织染色质、影响基因表达和表观遗传调控以及调节信号通路。核纤层与转录和复制机制的关键成分的瞬时相互作用可能为这些基本事件提供额外的调节或支持。
