核型共济失调。
Nuclear ataxias.
机构信息
Institute of Translational Neuroscience, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota 55455, USA.
出版信息
Cold Spring Harb Perspect Biol. 2010 May;2(5):a000786. doi: 10.1101/cshperspect.a000786.
Abstract
Historically basic neuroscience research has made several important contributions to the cell biology of the nucleus, in particular the elucidation of nuclear structures and compartments. As research progressed towards elucidating the mechanism of neurological disease at the cellular and molecular levels, it is now providing insight into the importance and basis of coordination of nuclear pathways within the nucleus and with other cellular compartments. Ataxias, lethal neurodegenerative diseases that are distinguished by a progressive loss of motor coordination, stem from disruption of nuclear function.
摘要
从历史上看，基础神经科学研究对核的细胞生物学做出了几项重要贡献，特别是阐明了核结构和隔室。随着研究向阐明细胞和分子水平的神经疾病机制的方向发展，它现在提供了对核途径在核内与其他细胞隔室之间协调的重要性和基础的深入了解。共济失调是一种致命的神经退行性疾病，其特征是运动协调逐渐丧失，源于核功能的破坏。
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