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1
ZAP-70: an essential kinase in T-cell signaling.
Cold Spring Harb Perspect Biol. 2010 May;2(5):a002279. doi: 10.1101/cshperspect.a002279.
2
The structure, regulation, and function of ZAP-70.
Immunol Rev. 2009 Mar;228(1):41-57. doi: 10.1111/j.1600-065X.2008.00753.x.
4
Structural basis for the inhibition of tyrosine kinase activity of ZAP-70.
Cell. 2007 May 18;129(4):735-46. doi: 10.1016/j.cell.2007.03.039.
5
Inhibition of ZAP-70 kinase activity via an analog-sensitive allele blocks T cell receptor and CD28 superagonist signaling.
J Biol Chem. 2008 May 30;283(22):15419-30. doi: 10.1074/jbc.M709000200. Epub 2008 Mar 31.
6
ZAP-70 in Signaling, Biology, and Disease.
Annu Rev Immunol. 2018 Apr 26;36:127-156. doi: 10.1146/annurev-immunol-042617-053335. Epub 2017 Dec 13.
7
An allosteric hot spot in the tandem-SH2 domain of ZAP-70 regulates T-cell signaling.
Biochem J. 2020 Apr 17;477(7):1287-1308. doi: 10.1042/BCJ20190879.
8
Stability of an autoinhibitory interface in the structure of the tyrosine kinase ZAP-70 impacts T cell receptor response.
Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20699-704. doi: 10.1073/pnas.0911512106. Epub 2009 Nov 17.
10
Sts-2 is a phosphatase that negatively regulates zeta-associated protein (ZAP)-70 and T cell receptor signaling pathways.
J Biol Chem. 2011 May 6;286(18):15943-54. doi: 10.1074/jbc.M110.177634. Epub 2011 Mar 10.

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Resolution of Squamous-Cell Carcinoma by Restoring T-Cell Receptor Signaling.
N Engl J Med. 2025 Jul 31;393(5):469-478. doi: 10.1056/NEJMoa2502114.
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Deciphering the deterministic role of TCR signaling in T cell fate determination.
Front Immunol. 2025 May 21;16:1562248. doi: 10.3389/fimmu.2025.1562248. eCollection 2025.
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Merocytophagy is an integrin-stabilized macrophage response to microbes reliant on Syk signaling.
Front Immunol. 2025 Apr 17;16:1565250. doi: 10.3389/fimmu.2025.1565250. eCollection 2025.
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Immune Checkpoint Molecules: A Review on Pathways and Immunotherapy Implications.
Immun Inflamm Dis. 2025 Apr;13(4):e70196. doi: 10.1002/iid3.70196.
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A self-activated and protective module enhances the preclinical performance of allogeneic anti-CD70 CAR-T cells.
Front Immunol. 2025 Jan 17;15:1531294. doi: 10.3389/fimmu.2024.1531294. eCollection 2024.
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Molecular Spies in Action: Genetically Encoded Fluorescent Biosensors Light up Cellular Signals.
Chem Rev. 2024 Nov 27;124(22):12573-12660. doi: 10.1021/acs.chemrev.4c00293. Epub 2024 Nov 13.
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Predicting protein interactions of the kinase Lck critical to T cell modulation.
Structure. 2024 Nov 7;32(11):2168-2179.e2. doi: 10.1016/j.str.2024.09.010. Epub 2024 Oct 4.

本文引用的文献

1
Stability of an autoinhibitory interface in the structure of the tyrosine kinase ZAP-70 impacts T cell receptor response.
Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20699-704. doi: 10.1073/pnas.0911512106. Epub 2009 Nov 17.
2
A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity.
J Exp Med. 2009 Oct 26;206(11):2527-41. doi: 10.1084/jem.20082902. Epub 2009 Oct 19.
3
The structure, regulation, and function of ZAP-70.
Immunol Rev. 2009 Mar;228(1):41-57. doi: 10.1111/j.1600-065X.2008.00753.x.
5
Inhibition of ZAP-70 kinase activity via an analog-sensitive allele blocks T cell receptor and CD28 superagonist signaling.
J Biol Chem. 2008 May 30;283(22):15419-30. doi: 10.1074/jbc.M709000200. Epub 2008 Mar 31.
7
ZAP-70 enhances IgM signaling independent of its kinase activity in chronic lymphocytic leukemia.
Blood. 2008 Mar 1;111(5):2685-92. doi: 10.1182/blood-2006-12-062265. Epub 2007 Nov 29.
8
Immune synapse formation requires ZAP-70 recruitment by ezrin and CD43 removal by moesin.
J Cell Biol. 2007 Nov 19;179(4):733-46. doi: 10.1083/jcb.200707199.
9
Distinct roles for Syk and ZAP-70 during early thymocyte development.
J Exp Med. 2007 Jul 9;204(7):1703-15. doi: 10.1084/jem.20070405. Epub 2007 Jul 2.
10
Structural basis for the inhibition of tyrosine kinase activity of ZAP-70.
Cell. 2007 May 18;129(4):735-46. doi: 10.1016/j.cell.2007.03.039.

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