Howard Hughes Medical Institute, Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, University of California, San Francisco, San Francisco, California 94143, USA.
Cold Spring Harb Perspect Biol. 2010 May;2(5):a002279. doi: 10.1101/cshperspect.a002279.
ZAP-70 is a cytoplasmic protein tyrosine kinase that plays a critical role in the events involved in initiating T-cell responses by the antigen receptor. Here we review the structure of ZAP-70, its regulation, its role in development and in disease. We also describe a model experimental system in which ZAP-70 function can be interrupted by a small chemical inhibitor.
ZAP-70 是一种细胞质蛋白酪氨酸激酶，在抗原受体引发 T 细胞反应所涉及的事件中发挥着关键作用。在这里，我们回顾了 ZAP-70 的结构、调节、在发育和疾病中的作用。我们还描述了一个实验模型系统，通过这个系统可以使用一种小分子化学抑制剂来阻断 ZAP-70 的功能。
