运动时血压反应过度与血清不对称二甲基精氨酸水平的关系。

Association between exaggerated blood pressure response to exercise and serum asymmetric dimethylarginine levels.

机构信息

Department of Cardiology, Selcuk University Meram School of Medicine Hospital, Meram, Konya, Turkey.

出版信息

Circ J. 2010 Jun;74(6):1135-41. doi: 10.1253/circj.cj-09-0419. Epub 2010 Apr 27.

DOI:10.1253/circj.cj-09-0419

PMID:20453387

Abstract

BACKGROUND

The exaggerated blood pressure response to exercise (EBPR) is an independent predictor of hypertension. Asymmetric dimethylarginine (ADMA) is an endogenous nitric oxide inhibitor and higher plasma levels of ADMA are related to increased cardiovascular risk. The aim of this study is to identify the relationship between ADMA and EBPR.

METHODS AND RESULTS

A total of 66 patients (36 with EBPR and 30 as controls) were enrolled in the study. EBPR is defined as blood pressure (BP) measurements > or =200/100 mmHg during the treadmill test. All the subjects underwent 24-h ambulatory BP monitoring. L-arginine and ADMA levels were measured using a high performance lipid chromatography technique. The serum ADMA levels were increased in the EBPR group compared to the healthy controls (4.0+/-1.4 vs 2.6+/-1.1 micromol/L respectively, P=0.001), but L-arginine levels were similar in the 2 groups (P=0.19). The serum ADMA levels were detected as an independent predictor of EBPR (odds ratio 2.28; 95% confidence interval 1.22-4.24; P=0.002).

CONCLUSIONS

Serum ADMA levels might play a role in EBPR to exercise.

摘要

背景

运动时血压反应过度（EBPR）是高血压的独立预测因子。不对称二甲基精氨酸（ADMA）是一种内源性一氧化氮抑制剂，较高的血浆 ADMA 水平与心血管风险增加有关。本研究旨在确定 ADMA 与 EBPR 之间的关系。

方法和结果

共纳入 66 例患者（36 例 EBPR 和 30 例作为对照组）。EBPR 定义为跑步机测试期间血压（BP）测量值>或=200/100mmHg。所有受试者均进行 24 小时动态血压监测。采用高效脂质色谱技术测定 L-精氨酸和 ADMA 水平。与健康对照组相比，EBPR 组的血清 ADMA 水平升高（分别为 4.0+/-1.4 和 2.6+/-1.1 umol/L，P=0.001），但两组的 L-精氨酸水平相似（P=0.19）。血清 ADMA 水平可作为 EBPR 的独立预测因子（优势比 2.28；95%置信区间 1.22-4.24；P=0.002）。