Michishita Ryoma, Ohta Masanori, Ikeda Masaharu, Jiang Ying, Yamato Hiroshi
Department of Health Development, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Kitakyushu, Japan.
International College of Arts and Sciences, Department of Food and Health Science, Fukuoka Women's University, Fukuoka, Japan.
Hypertens Res. 2016 Nov;39(11):792-798. doi: 10.1038/hr.2016.75. Epub 2016 Jun 23.
This study was designed to examine the associations of an exaggerated systolic blood pressure (SBP) response to exercise with the indices of nitric oxide (NO) bioavailability, oxidative stress, inflammation and arterial stiffness in normotensive females. The subjects included 84 normotensive females without a history of cardiovascular disease or stroke who were not taking any medications. Each subject performed a multistage graded submaximal exercise stress test using an electric bicycle ergometer, and their blood pressure was measured at rest and during the last minute of each stage. The brachial-ankle pulse wave velocity, plasma nitrate/nitrite (NO), plasma thiobarbituric acid-reactive substances, high-sensitivity C-reactive protein (hs-CRP) and fibrinogen levels and the white blood cell count were measured. An exaggerated SBP response to exercise was defined according to the criteria of the Framingham Study (peak SBP: ⩾190 mm Hg). An exaggerated SBP response to exercise was observed in 27 subjects. A multiple logistic regression analysis revealed that the hs-CRP (odds ratio (OR): 1.05, 95% confidence interval (CI): 1.03-1.07, P=0.015) and plasma NO levels (OR: 0.92, 95% CI: 0.87-0.98, P=0.014) were significantly associated with an exaggerated SBP response to exercise. Furthermore, the percent change in SBP was found to be significantly associated with an increase in the hs-CRP (P for trend=0.006) and a decrease in the plasma NO levels (P for trend=0.001). These results suggest that an exaggerated SBP response to exercise was associated with the NO bioavailability and inflammatory status in normotensive females.
本研究旨在探讨血压正常女性运动时收缩压（SBP）反应过度与一氧化氮（NO）生物利用度、氧化应激、炎症及动脉僵硬度指标之间的关联。研究对象包括84名无心血管疾病或中风病史且未服用任何药物的血压正常女性。每位受试者使用电动自行车测力计进行多级次极量运动应激试验，并在静息状态及每个阶段的最后一分钟测量其血压。测量肱踝脉搏波速度、血浆硝酸盐/亚硝酸盐（NO）、血浆硫代巴比妥酸反应性物质、高敏C反应蛋白（hs-CRP）和纤维蛋白原水平以及白细胞计数。根据弗雷明汉姆研究标准（峰值SBP：⩾190 mmHg）定义运动时SBP反应过度。27名受试者出现运动时SBP反应过度。多因素logistic回归分析显示，hs-CRP（比值比（OR）：1.05，95%置信区间（CI）：1.03 - 1.07，P = 0.015）和血浆NO水平（OR：0.92，95% CI：0.87 - 0.98，P = 0.014）与运动时SBP反应过度显著相关。此外，发现SBP的变化百分比与hs-CRP升高（趋势P = 0.006）和血浆NO水平降低（趋势P = 0.001）显著相关。这些结果表明，血压正常女性运动时SBP反应过度与NO生物利用度及炎症状态有关。
