冠状动脉支架置入后光学相干断层扫描显示支架梁周围低强度区。
Intriguing peri-strut low-intensity area detected by optical coherence tomography after coronary stent deployment.
机构信息
Department of Cardiovascular Medicine, Stanford University, Stanford, CA, USA.
出版信息
Circ J. 2010 Jun;74(6):1257-9. doi: 10.1253/circj.cj-10-0189. Epub 2010 Apr 29.
BACKGROUND
Although peri-strut low-intensity area (PLIA) is frequently observed on post-stenting optical coherence tomography (OCT) images, the histology associated with PLIA is undocumented.
METHODS AND RESULTS
The 36 porcine coronary lesions treated with bare-metal (BMS: n=16) or drug-eluting (DES: n=20) stents were assessed by OCT and histology at 28 days. DES showed a significantly higher incidence of PLIA than BMS. Also, +PLIA stents had greater neointima than PLIA stents. Histological analysis revealed the existence of fibrinoid and proteoglycans at the site of PLIA.
CONCLUSIONS
PLIA might be represented by the presence of fibrinoid and proteoglycans, and associated with neointimal proliferation after stenting.
背景
尽管支架内低强度区域（PLIA）在支架置入后的光学相干断层扫描（OCT）图像中经常观察到，但与 PLIA 相关的组织学尚未记录。
方法和结果
36 个猪冠状动脉病变分别接受了金属裸支架（BMS：n=16）或药物洗脱支架（DES：n=20）治疗，在 28 天时通过 OCT 和组织学进行评估。DES 显示 PLIA 的发生率明显高于 BMS。此外，+PLIA 支架的新生内膜比 PLIA 支架更大。组织学分析显示 PLIA 部位存在纤维蛋白和糖胺聚糖。
结论
PLIA 可能代表纤维蛋白和糖胺聚糖的存在，并与支架置入后的新生内膜增殖有关。
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