San Gallicano Dermatological Institute, Via Chianesi 53, Rome, Italy.
Dermatology. 2010;220(4):346-54. doi: 10.1159/000297561. Epub 2010 May 6.
Kaposi's sarcoma (KS) is an unusual, clinically polymorphic, vascular neoplasm with genetic, infectious, environmental and immunological pathogenesis. Reflectance confocal microscopy (RCM) made in vivo noninvasive imaging of the skin possible and has been used for the evaluation of several skin diseases offering important microscopic information.
The purpose of our study is to describe the RCM features of KS and correlate them with histopathology evaluating the effective prediction attitude and repeatability of RCM.
Twelve KS lesions underwent RCM followed by histological examination. Data obtained were statistically correlated.
Analysis of the incidence of 11 selected microscopic criteria (by RCM and optical histology: inflammatory cells in the epidermis and in the dermis, single or in aggregates; spindle cells; stroma; anastomosing, newborn, increased number and dilated vessels; extravasated erythrocytes; deposits of hemosiderin) was performed disclosing a good correlation and high sensitivity of RCM.
In our study RCM seems to provide high accuracy to predict histological findings, demonstrating its possible role in the management of patients affected by KS.
卡波西肉瘤（KS）是一种不常见的、临床表现多样的血管性肿瘤，其发病机制涉及遗传、感染、环境和免疫等多个方面。共聚焦激光扫描显微镜（RCM）可对皮肤进行非侵入性的活体成像，已被用于评估多种皮肤疾病，提供重要的微观信息。
本研究旨在描述 KS 的 RCM 特征，并将其与组织病理学相关联，评估 RCM 的有效预测能力和可重复性。
对 12 例 KS 病变进行 RCM 检查及组织学检查。对获得的数据进行了统计学相关性分析。
对 11 项选定的微观标准（RCM 和光学组织学：表皮和真皮中的炎症细胞，单个或聚集；梭形细胞；基质；吻合、新生、数量增加和扩张的血管；红细胞外渗；含铁血黄素沉积）的发生率进行了分析，结果显示 RCM 具有良好的相关性和较高的灵敏度。
在本研究中，RCM 似乎能够高度准确地预测组织学发现，表明其在 KS 患者的管理中可能具有一定作用。
