Drug Commission of the German Medical Association, Berlin, Germany. bmoe @ zedat.fu-berlin.de
Neuropsychobiology. 2010;62(1):43-9. doi: 10.1159/000314309. Epub 2010 May 7.
From a practical point of view, the well-proven antisuicidal and anti-aggressive effects of lithium are of utmost importance for a rational, safe and economical treatment of patients with affective disorders. Regular lithium long-term treatment reduces the otherwise 2- to 3-fold increased mortality of untreated patients with severe affective disorders down to the level of the general population. This is mainly due to the reduced suicide risk. Many international studies have confirmed this fascinating property of lithium which so far has not been demonstrated with comparable evidence for any other psychotropic compound. The antisuicidal effects of lithium might possibly be related to its anti-aggressive effects which have been shown in various species, populations and settings, such as animals, inhabitants of nursing homes for the elderly, mentally handicapped subjects, children and adolescents with hyperactive, hostile and aggressive behavior, and particularly in hyperaggressive inmates of correction units and prisons.
从实际角度来看，锂的抗自杀和抗攻击作用已被充分证实，对于合理、安全和经济地治疗情感障碍患者具有至关重要的意义。定期进行锂的长期治疗可将未经治疗的重症情感障碍患者的死亡率从原本的 2 到 3 倍降低至普通人群的水平。这主要是由于自杀风险降低了。许多国际研究都证实了锂的这种令人着迷的特性，而到目前为止，还没有任何其他精神药物能够具有可比的证据来证明这一点。锂的抗自杀作用可能与其抗攻击作用有关，在各种物种、人群和环境中，如动物、养老院的居民、智力障碍者、有过度活跃、敌对和攻击性行为的儿童和青少年，以及在矫正机构和监狱中具有过度攻击性的囚犯中，都已经证明了锂的抗攻击作用。
