Neuroscience Institute and Brain Tumor Center, John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, California 90404, USA.
Curr Opin Endocrinol Diabetes Obes. 2010 Aug;17(4):369-76. doi: 10.1097/MED.0b013e32833abcba.
Over the past four decades, advances in surgical technique, instrumentation, and anatomical knowledge have fueled the evolution and sophistication of transsphenoidal pituitary surgery. Paralleling these advances have been major improvements in endocrinological and overall clinical outcomes in patients with pituitary adenomas and other parasellar lesions such as Rathke's cleft cysts and craniopharyngiomas. In this review, we assess the impact of neurosurgeon expertise as a determinant of outcome in pituitary surgery.
Published data since the 1980s indicate that remission rates, overall clinical outcomes and surgical complication rates in pituitary and parasellar surgery are related to neurosurgeon practice volume and cumulative clinical experience. More recently, pituitary surgery has been increasingly performed using an endonasal endoscopic approach. Reports over the last decade suggest when an experienced pituitary neurosurgeon performs a fully endoscopic or endoscope-assisted tumor removal; outcomes are similar if not better than when performed by a traditional microscopic transsphenoidal approach.
A focused clinical practice and large transsphenoidal surgical volume appear to be important outcome determinants for patients with pituitary and parasellar tumors. Strategies that may further improve patient outcomes include establishing guidelines for pituitary tumor centers of excellence and more focused residency and fellowship training in endonasal endoscopic transsphenoidal surgery. Encouraging regionalization of care to higher volume pituitary tumor centers of excellence and promoting patient education on the importance of surgical expertise may further enhance pituitary patient outcomes.
在过去的四十年中,手术技术、器械和解剖知识的进步推动了经蝶窦垂体手术的发展和完善。与这些进步并行的是,垂体腺瘤和其他鞍旁病变(如 Rathke 裂囊肿和颅咽管瘤)患者的内分泌学和整体临床结局有了重大改善。在这篇综述中,我们评估了神经外科医生专业知识作为垂体手术结果的决定因素的影响。
自 20 世纪 80 年代以来发表的数据表明,垂体和鞍旁手术的缓解率、整体临床结局和手术并发症率与神经外科医生的实践量和累积临床经验有关。最近,经鼻内镜入路越来越多地用于垂体手术。过去十年的报告表明,当经验丰富的垂体神经外科医生进行全内镜或内镜辅助肿瘤切除时,如果由传统的显微镜经蝶窦入路进行,结果相似甚至更好。
集中的临床实践和大量的经蝶窦手术量似乎是垂体和鞍旁肿瘤患者的重要结局决定因素。可能进一步改善患者结局的策略包括为垂体肿瘤卓越中心制定指南,以及在经鼻内镜经蝶窦手术方面进行更有针对性的住院医师和研究员培训。鼓励将医疗服务区域化到更高容量的垂体肿瘤卓越中心,并促进患者对手术专业知识重要性的教育,可能会进一步提高垂体患者的结局。