早产缺血性中风患者的后代是否需要医生针对一级预防给予密切关注？一项试点研究。

Does the progeny of premature ischemic stroke sufferers need intensive interest of physicians oriented toward primary prevention? A pilot study.

作者信息

Mierzecki Artur, Kozłowska-Wojciechowska Małgorzata, Bukowska Hanna, Makarewicz-Wujec Magdalena, Honczarenko Krystyna, Chełstowski Kornel, Jastrzębska Maria, Masztalewicz Marta

机构信息

Independent Laboratory of Family Physician Education, Pomeranian Medical University, ul. Rybacka 1, Szczecin, Poland.

出版信息

Eur J Cardiovasc Prev Rehabil. 2010 Dec;17(6):725-9. doi: 10.1097/HJR.0b013e32833a1995.

DOI:10.1097/HJR.0b013e32833a1995

PMID:20453653

Abstract

BACKGROUND

Few studies focus on the progeny of stroke patients with respect to the occurrence of other potential risk factors.

METHODS

The study group covered 60 males and 62 females whose parents had suffered premature ischemic stroke (PIS); the control group comprised of 41 males and 47 females whose parents had no history of premature vascular event (mean age: 28.4 and 27.1 years, respectively). Examination of both the groups consisted of evaluation of their diet, measurement of arterial blood pressure and body mass index (BMI). Moreover, blood test was carried out and concentration of biochemical stroke risk factors was determined.

RESULTS

The adult progeny of parents with a history of PIS followed a deficient, unbalanced, and nonvaried diet. Their average blood pressure and BMI reached higher values, compared with the results obtained in the control group (125.7±16.06 vs. 122.64±10.83 mmHg; 24.27±3.98 vs. 22.54±2.69 kg/m, respectively; P<0.05). The same applies to average concentrations of the triglycerides 1.22±0.76 vs. 1.06±0.54 mmol/l; total cholesterol (5.34±1.16 vs. 4.82±0.89 mmol/l), low-density lipoprotein-cholesterol (2.95±0.97 vs. 2.52±0.73 mmol/l), total homocysteine (11.22±4.22 vs. 10.18±2.45 μmol/l), and fibrinogen (2.91±0.68 vs. 2.78±0.6 g/l) (P<0.05).

CONCLUSION

Adult children of PIS sufferers show different stroke risk factor profiles than the control group. It may indicate a need for preventive activities for this group in the future. Family occurrence of stroke requires further detailed studies on a larger cohort of patients from risk group.

摘要

背景

很少有研究关注中风患者的后代出现其他潜在风险因素的情况。

方法

研究组包括60名男性和62名女性，他们的父母曾患过早发性缺血性中风（PIS）；对照组由41名男性和47名女性组成，他们的父母没有过早发生血管事件的病史（平均年龄分别为28.4岁和27.1岁）。两组的检查包括饮食评估、动脉血压测量和体重指数（BMI）测量。此外，还进行了血液检测并测定了生化中风风险因素的浓度。

结果

有PIS病史的父母的成年后代饮食不足、不均衡且单一。与对照组相比，他们的平均血压和BMI值更高（分别为125.7±16.06 vs. 122.64±10.83 mmHg；24.27±3.98 vs. 22.54±2.69 kg/m²；P<0.05）。甘油三酯、总胆固醇、低密度脂蛋白胆固醇、总同型半胱氨酸和纤维蛋白原的平均浓度情况也是如此（分别为1.22±0.76 vs. 1.06±0.54 mmol/l；5.34±1.16 vs. 4.82±0.89 mmol/l；2.95±0.97 vs. 2.52±0.73 mmol/l；11.22±4.22 vs. 10.18±2.45 μmol/l；2.91±0.68 vs. 2.78±0.6 g/l）（P<0.05）。