Department of Medicine, University of Alabama at Birmingham, 1530 3rd Avenue S., Birmingham, AL 35294, USA.
Sex Transm Dis. 2010 Jun;37(6):392-6. doi: 10.1097/OLQ.0b013e3181dd1691.
Trichomoniasis is associated with adverse pregnancy outcomes and increased risk for human immunodeficiency virus. Males are usually asymptomatic, and thus there is heavy reliance on partner notification for identifying infected male partners. The usual approach is partner referral but it is estimated that only a minority of men seek care. We conducted a randomized trial to compare the effectiveness of 3 methods of partner notification.
Women were randomized to self-referral of partners (PR), partner-delivered therapy (PDPT), or public health disease intervention (DIS) locating partners and delivering medication in the field, if needed. Test-of-cure visits were conducted at 5 to 9 days after enrollment. Repeat infections at 1 and 3 months of follow-up were the measure of effectiveness.
A total of 484 women were randomized. Initial cure rates were 95.3%. At the 1- and 3-month follow-up visits, there was no significant difference in repeat infection rates when PDPT or DIS were compared to the reference of PR. However, when PDPT was compared to DIS or PR/DIS combined, at 1 month the PDPT group had a lower repeat infection rate (5.8 vs. 15% and 5.8 vs. 12.5%, respectively). Of these, 80% of women randomized to PDPT reported delivering medication and 89% thought it likely that partners took the medication. No serious adverse events were reported.
PDPT for trichomoniasis was well accepted and safe in this study. Rates of repeat infection in women in this intervention were lower than those in the DIS arm and DIS/PR arm combined although when compared directly to PR there was no significant difference.
滴虫病与不良妊娠结局和人类免疫缺陷病毒感染风险增加有关。男性通常无症状，因此主要依赖于性伴侣通知来识别感染的男性伴侣。通常的方法是性伴侣转介，但据估计只有少数男性寻求治疗。我们进行了一项随机试验，比较了三种性伴侣通知方法的有效性。
女性被随机分配到自行转介伴侣（PR）、伴侣提供治疗（PDPT）或公共卫生疾病干预（DIS），即现场寻找伴侣并提供药物，如果需要的话。治愈测试在登记后 5 至 9 天进行。随访 1 个月和 3 个月时的重复感染是有效性的衡量标准。
共有 484 名女性被随机分配。初始治愈率为 95.3%。在 1 个月和 3 个月的随访中，与 PR 相比，PDPT 或 DIS 与重复感染率无显著差异。然而，当将 PDPT 与 DIS 或 PR/DIS 联合比较时，在 1 个月时，PDPT 组的重复感染率较低（5.8%比 15%和 5.8%比 12.5%）。其中，80%的随机分配到 PDPT 的女性报告了药物的传递，89%的女性认为伴侣很可能服用了药物。没有报告严重不良事件。
在这项研究中，PDPT 治疗滴虫病的效果良好且安全。尽管与 PR 直接比较时没有显著差异，但与 DIS 组和 DIS/PR 联合组相比，该干预组女性的重复感染率较低。
