α-连环蛋白机械感知黏着连接。
alpha-catenin mechanosensing for adherens junctions.
机构信息
Thomas Lecuit is in IBDML, UMR6216 CNRS-Université de la Méditerranée, Campus de Luminy, Case 907. 13288 Marseille Cedex 09, France.
出版信息
Nat Cell Biol. 2010 Jun;12(6):522-4. doi: 10.1038/ncb2066. Epub 2010 May 9.
DOI:10.1038/ncb2066
PMID:20453846
Abstract
The balance of cohesion and remodelling is essential for the integrity and morphogenesis of epithelia. This requires adhesion and transmission of actomyosin tension, both of which are mediated by E-cadherin. The finding that actomyosin tension reinforces mechanical coupling of actin to E-cadherin through alpha-catenin reveals similarities with integrin regulation.
摘要
上皮细胞的完整性和形态发生需要黏附和肌动球蛋白张力的传递，这两者都由 E-钙黏蛋白介导。肌动球蛋白张力通过α-连环蛋白增强肌动蛋白与 E-钙黏蛋白的机械偶联，这一发现揭示了其与整合素调节的相似性。
Zotero 插件