蜂毒明肽对大鼠和猫胃底对血管活性肠肽、三磷酸腺苷及非肾上腺素能非胆碱能神经元刺激反应的影响。
Effect of apamin on the responses to VIP, ATP and NANC neurone stimulation in the rat and cat gastric fundus.
作者信息
Lefebvre R A, de Beurme F A, Sas S
机构信息
Heymans Institute of Pharmacology, University of Gent Medical School, Belgium.
出版信息
J Auton Pharmacol. 1991 Apr;11(2):73-83. doi: 10.1111/j.1474-8673.1991.tb00246.x.
Abstract
- The influence of apamin on non-adrenergic non-cholinergic (NANC) relaxation and on the effect of the putative transmitters VIP and ATP was examined in the rat and cat gastric fundus. 2. In longitudinal muscle strips of the rat gastric fundus, ATP induced a biphasic effect, relaxation followed by contraction. The relaxant effect of ATP was blocked by apamin, whereas the relaxations induced by VIP and NANC neurone stimulation were not influenced by apamin. 3. In circular and longitudinal muscle strips of the cat gastric fundus, ATP only induced relaxation at high concentrations. The ATP-induced relaxation was increased in the presence of apamin, whereas the VIP-induced and NANC relaxations were not influenced. 4. It is concluded that the relaxant effect of ATP might be related to activation of apamin-sensitive Ca(2+)-dependent K(+)-channels in the rat gastric fundus. In the cat gastric fundus, apamin did not antagonize the relaxant effect of ATP so that it cannot be used to investigate an ATP involvement in inhibitory NANC neurotransmission in this tissue. No evidence for a presynaptic inhibitory action of apamin on VIP-ergic NANC neurones was obtained.
摘要
- 在大鼠和猫的胃底，研究了蜂毒明肽对非肾上腺素能非胆碱能（NANC）舒张以及对假定递质血管活性肠肽（VIP）和三磷酸腺苷（ATP）作用的影响。2. 在大鼠胃底纵行肌条中，ATP引起双相效应，先是舒张，随后是收缩。ATP的舒张作用被蜂毒明肽阻断，而VIP和NANC神经元刺激所诱导的舒张不受蜂毒明肽影响。3. 在猫胃底的环行肌条和纵行肌条中，ATP仅在高浓度时诱导舒张。在存在蜂毒明肽的情况下，ATP诱导的舒张增强，而VIP诱导的舒张和NANC舒张不受影响。4. 得出结论：在大鼠胃底，ATP的舒张作用可能与激活蜂毒明肽敏感的钙依赖性钾通道有关。在猫胃底，蜂毒明肽不拮抗ATP的舒张作用，因此不能用它来研究ATP在该组织中参与抑制性NANC神经传递的情况。未获得蜂毒明肽对VIP能NANC神经元有突触前抑制作用的证据。
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