Zhang Weibo, Yelick Pamela C
Division of Craniofacial and Molecular Genetics, Department of Oral and Maxillofacial Pathology, Tufts University, 136 Harrison Avenue, Room M824, Boston, MA 02111, USA.
Int J Dent. 2010;2010:856087. doi: 10.1155/2010/856087. Epub 2010 Apr 28.
Pulp vitality is extremely important for the tooth viability, since it provides nutrition and acts as biosensor to detect pathogenic stimuli. In the dental clinic, most dental pulp infections are irreversible due to its anatomical position and organization. It is difficult for the body to eliminate the infection, which subsequently persists and worsens. The widely used strategy currently in the clinic is to partly or fully remove the contaminated pulp tissue, and fill and seal the void space with synthetic material. Over time, the pulpless tooth, now lacking proper blood supply and nervous system, becomes more vulnerable to injury. Recently, potential for successful pulp regeneration and revascularization therapies is increasing due to accumulated knowledge of stem cells, especially dental pulp stem cells. This paper will review current progress and feasible strategies for dental pulp regeneration and revascularization.
牙髓活力对牙齿的生存能力极为重要，因为它提供营养并作为生物传感器来检测致病刺激。在牙科诊所，由于牙髓的解剖位置和结构，大多数牙髓感染是不可逆的。身体很难消除感染，感染随后会持续并恶化。目前临床上广泛使用的策略是部分或完全去除受污染的牙髓组织，并用合成材料填充和封闭空隙。随着时间的推移，现在缺乏适当血液供应和神经系统的无髓牙变得更容易受到损伤。最近，由于对干细胞，尤其是牙髓干细胞的认识不断积累，牙髓再生和血管再生治疗成功的可能性正在增加。本文将综述牙髓再生和血管再生的当前进展及可行策略。
