Li Yao, Shu Li-Hong, Yan Ming, Dai Wen-Yong, Li Jun-Jun, Zhang Guang-Dong, Yu Jin-Hua
Yao Li, Li-Hong Shu, Ming Yan, Wen-Yong Dai, Jun-Jun Li, Guang-Dong Zhang, Jin-Hua Yu, Institute of Stomatology, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
World J Methodol. 2014 Jun 26;4(2):99-108. doi: 10.5662/wjm.v4.i2.99.
Generally, the dental pulp needs to be removed when it is infected, and root canal therapy (RCT) is usually required in which infected dental pulp is replaced with inorganic materials (paste and gutta percha). This treatment approach ultimately brings about a dead tooth. However, pulp vitality is extremely important to the tooth itself, since it provides nutrition and acts as a biosensor to detect the potential pathogenic stimuli. Despite the reported clinical success rate, RCT-treated teeth are destined to be devitalized, brittle and susceptible to postoperative fracture. Recently, the advances and achievements in the field of stem cell biology and regenerative medicine have inspired novel biological approaches to apexogenesis in young patients suffering from pulpitis or periapical periodontitis. This review mainly focuses on the benchtop and clinical regeneration of root apex mediated by adult stem cells. Moreover, current strategies for infected pulp therapy are also discussed here.
一般来说，牙髓感染时需要将其去除，通常需要进行根管治疗（RCT），即用无机材料（糊剂和牙胶）替代感染的牙髓。这种治疗方法最终会导致牙齿坏死。然而，牙髓活力对牙齿本身极为重要，因为它提供营养并作为生物传感器来检测潜在的致病刺激。尽管报道的临床成功率较高，但接受根管治疗的牙齿注定会失去活力、变脆且易发生术后骨折。最近，干细胞生物学和再生医学领域的进展与成就激发了针对患有牙髓炎或根尖周炎的年轻患者进行根尖形成的新型生物学方法。本综述主要关注成体干细胞介导的根尖的实验台研究和临床再生。此外，这里还讨论了当前感染牙髓治疗的策略。
