Department of Vascular and Endovascular Surgery, Faculdade de Medicina da Universidade de São Paulo, Hospital das Clínicas, São Paulo, Brazil.
Clinics (Sao Paulo). 2010 Apr;65(4):383-7. doi: 10.1590/S1807-59322010000400006.
To investigate whether oxidized low-density lipoprotein is a suitable predictor of peripheral arterial disease severity. The role of oxidized low-density lipoprotein in the pathogenesis of atherosclerosis has already been investigated. Its relevance as a predictor of the appearance and worsening of coronary arterial disease is also well known. However, the same is not true regarding peripheral arterial disease.
Eighty-five consecutive patients with an ankle-brachial pressure index (ABPI) < 0.9 and the presence of either intermittent claudication or critical lower leg ischemia were included. The plasma level of IgG autoantibodies against oxidized low-density lipoprotein was evaluated through an enzyme-linked immunosorbent assay. The results were categorized into quartiles according to the ankle-brachial pressure index (a marker of peripheral arterial disease severity), and significant differences were investigated with the Kruskal-Wallis test.
There was no significant difference between the quartiles for this population (p = 0.33). No correlation was found between the ankle-brachial pressure index and oxidized low-density lipoprotein levels in subjects with clinically evident peripheral arterial disease with a wide range of clinical manifestations.
Oxidized low-density lipoprotein is not a good predictor of peripheral arterial disease severity.
探讨氧化型低密度脂蛋白是否是外周动脉疾病严重程度的合适预测因子。氧化型低密度脂蛋白在动脉粥样硬化发病机制中的作用已经得到了研究。其作为冠状动脉疾病发生和恶化的预测因子的相关性也众所周知。然而，对于外周动脉疾病来说并非如此。
纳入 85 例踝肱指数（ABI）<0.9 且存在间歇性跛行或小腿严重缺血的连续患者。通过酶联免疫吸附试验评估 IgG 针对氧化型低密度脂蛋白的自身抗体的血浆水平。根据踝肱指数（外周动脉疾病严重程度的标志物）将结果分为四组，并使用 Kruskal-Wallis 检验进行了显著性差异研究。
该人群的四个四分位数之间没有显著差异（p=0.33）。在临床表现范围广泛的有临床明显外周动脉疾病的患者中，踝肱指数与氧化型低密度脂蛋白水平之间没有相关性。
氧化型低密度脂蛋白不是外周动脉疾病严重程度的良好预测因子。
