Department of Medicine Cardiovascular Section, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73117, USA.
Angiology. 2010 Oct;61(7):698-704. doi: 10.1177/0003319710369100. Epub 2010 Jun 7.
Women with peripheral arterial disease (PAD) have more limited physical function than men but the mechanisms involved are not clear. We determined whether alterations in lipid components, such as decreased high-density lipoprotein cholesterol (HDL-C), are associated with worsening intermittent claudication (IC) in postmenopausal women with PAD. Our cross-sectional cohort study included 69 postmenopausal women with IC (Fontaine stage II). A treadmill test was used to measure initial claudication distance (ICD), absolute claudication distance (ACD), peak oxygen uptake, and ankle systolic blood pressure. High-density lipoprotein cholesterol correlated with ankle brachial index ([ABI]; R = .29, P = .019). No other lipid profile components were associated with exercise performance and hemodynamic measures. Among women with HDL-C <50 mg/dL (n = 43), the median peak oxygen uptake level was significantly lower (P = .021) relative to women with normal HDL-C >50 mg/dL (n = 26). Lower HDL-C levels are associated with worse ABI and decreased peak oxygen uptake in postmenopausal women with PAD.
患有外周动脉疾病（PAD）的女性的身体功能比男性更受限，但涉及的机制尚不清楚。我们确定了脂质成分的改变，如高密度脂蛋白胆固醇（HDL-C）降低，是否与绝经后患有 PAD 的女性间歇性跛行（IC）恶化有关。我们的横断面队列研究包括 69 名患有 IC（Fontaine Ⅱ期）的绝经后女性。跑步机测试用于测量初始跛行距离（ICD）、绝对跛行距离（ACD）、峰值耗氧量和踝部收缩压。高密度脂蛋白胆固醇与踝肱指数（ABI；R =.29，P =.019）相关。其他血脂谱成分与运动表现和血液动力学测量无关。在 HDL-C <50mg/dL 的女性中（n = 43），与 HDL-C >50mg/dL 的女性相比（n = 26），中位峰值耗氧量水平显著降低（P =.021）。较低的 HDL-C 水平与绝经后 PAD 女性的 ABI 降低和峰值耗氧量降低有关。
