Langlois Michel R, Rietzschel Ernst R, De Buyzere Marc L, De Bacquer Dirk, Bekaert Sofie, Blaton Victor, De Backer Guy G, Gillebert Thierry C
Department of Clinical Chemistry, AZ St-Jan Hospital, Ruddershove 10, B-8000, Bruges, Belgium.
Arterioscler Thromb Vasc Biol. 2008 Aug;28(8):1563-8. doi: 10.1161/ATVBAHA.108.167346. Epub 2008 May 29.
Reported associations of oxidized low-density lipoprotein (oxLDL) with noninvasive measures of atherosclerosis are inconsistent. In the Asklepios Study cohort of asymptomatic subjects aged 35 to 55 years, we evaluated the relationship of circulating oxLDL with subclinical atherosclerosis in the carotid and femoral arteries.
Participants (n=2524, 51.5% females) completed a study questionnaire and underwent a clinical examination, blood analysis of oxLDL (mAb-4E6) and other risk markers, and ultrasound examination of intima-media thickness (IMT) and plaques in the left and right carotid and femoral arteries. oxLDL concentrations were highest in subjects with femoral plaques (n=658). In the group of subjects with carotid plaques (n=476), elevated oxLDL concentrations are related to concomitant femoral plaques detected in 54% of these subjects. Multivariate regression analyses (including anthropometric, hemodynamic, biochemical, and lifestyle variables) showed that femoral plaques are independently related to oxLDL whereas femoral IMT, carotid IMT, or carotid plaques were not independently associated with oxLDL.
Circulating oxLDL is independently associated with femoral plaque and not with carotid artery wall damage.
氧化型低密度脂蛋白（oxLDL）与动脉粥样硬化非侵入性测量指标之间的关联报道并不一致。在Asklepios研究队列中，针对年龄在35至55岁的无症状受试者，我们评估了循环oxLDL与颈动脉和股动脉亚临床动脉粥样硬化之间的关系。
参与者（n = 2524，51.5%为女性）完成了一份研究问卷，并接受了临床检查、oxLDL（单克隆抗体-4E6）及其他风险标志物的血液分析，以及左右颈动脉和股动脉内膜中层厚度（IMT）和斑块的超声检查。在有股动脉斑块的受试者（n = 658）中，oxLDL浓度最高。在有颈动脉斑块的受试者组（n = 476）中，oxLDL浓度升高与这些受试者中54%检测到的伴随股动脉斑块有关。多变量回归分析（包括人体测量、血液动力学、生化和生活方式变量）显示，股动脉斑块与oxLDL独立相关，而股动脉IMT、颈动脉IMT或颈动脉斑块与oxLDL无独立关联。
循环oxLDL与股动脉斑块独立相关，而与颈动脉壁损伤无关。
