Department of Histopathology, Nottingham University Hospitals, Queens Medical Centre Campus, University of Nottingham, NG7 2UH Nottingham, UK.
J Oncol. 2010;2010:701476. doi: 10.1155/2010/701476. Epub 2010 Apr 29.
Intrahepatic sarcomatoid cholangiocarcinoma is a rare but an aggressive variant of cholangiocarcinoma with a very poor prognosis. We report the first caucasian patient who presented with a rapidly enlarging liver mass requiring hepatic resection. Detailed histopathological analyses including immunohistochemistry and electron microscopy confirmed sarcomatoid cholangiocarcinoma. The patient had early onset disease recurrence within 5 weeks of surgery. Here we demonstrate that combination chemotherapy with gemcitabine and cisplatin is a potential treatment option in patients with advanced sarcomatous cholangiocarcinoma. The patient achieved sustained partial remission with combination chemotherapy and remains alive and well more than 29 months since initial surgery.
肝内肉瘤样胆管细胞癌是一种罕见但侵袭性很强的胆管癌，预后极差。我们报告了首例表现为迅速增大的肝肿块、需要进行肝切除术的高加索患者。详细的组织病理学分析包括免疫组织化学和电子显微镜检查证实为肉瘤样胆管细胞癌。患者在手术后 5 周内即出现早期疾病复发。在此，我们证明吉西他滨和顺铂联合化疗是晚期肉瘤样胆管癌患者的一种潜在治疗选择。该患者接受联合化疗后获得持续的部分缓解，并且自初始手术以来已经超过 29 个月仍然存活且状况良好。
