皮肤黑色素瘤：丝氨酸蛋白酶抑制剂的生理和治疗方面概述及生物技术应用。
Cutaneous Melanoma: An Overview of Physiological and Therapeutic Aspects and Biotechnological Use of Serine Protease Inhibitors.
机构信息
Laboratory of Protein Purification and Their Biological Functions, Food Technology and Public Health Unit, Federal University of Mato Grosso do Sul (UFMS), Campo Grande 79070-900, MS, Brazil.
Departamento de Bioquímica, Universidade Federal de São Paulo (UNIFESP), São Paulo 04023-062, SP, Brazil.
出版信息
Molecules. 2024 Aug 16;29(16):3891. doi: 10.3390/molecules29163891.
BACKGROUND
Metastatic melanoma stands out as the most lethal form of skin cancer because of its high propensity to spread and its remarkable resistance to treatment methods.
METHODS
In this review article, we address the incidence of melanoma worldwide and its staging phases. We thoroughly investigate the different melanomas and their associated risk factors. In addition, we underscore the principal therapeutic goals and pharmacological methods that are currently used in the treatment of melanoma.
RESULTS
The implementation of targeted therapies has contributed to improving the approach to patients. However, because of the emergence of resistance early in treatment, overall survival and progression-free periods continue to be limited.
CONCLUSIONS
We provide new insights into plant serine protease inhibitor therapeutics, supporting high-throughput drug screening soon, and seeking a complementary approach to explain crucial mechanisms associated with melanoma.
背景
转移性黑色素瘤是最致命的皮肤癌形式，因为它具有高度的扩散倾向和对治疗方法的显著抵抗力。
方法
在这篇综述文章中，我们讨论了全球黑色素瘤的发病率及其分期阶段。我们深入研究了不同的黑色素瘤及其相关的危险因素。此外，我们强调了目前用于治疗黑色素瘤的主要治疗目标和药理学方法。
结果
靶向治疗的实施有助于改善患者的治疗方法。然而，由于治疗早期出现耐药性，总体生存和无进展期仍然有限。
结论
我们为植物丝氨酸蛋白酶抑制剂治疗提供了新的见解，支持高通量药物筛选尽快进行，并寻求一种补充方法来解释与黑色素瘤相关的关键机制。
Zotero 插件