Xie M H, Aggarwal S, Ho W H, Foster J, Zhang Z, Stinson J, Wood W I, Goddard A D, Gurney A L
Department of Molecular Biology, Genentech, Inc., South San Francisco, California 94080, USA.
J Biol Chem. 2000 Oct 6;275(40):31335-9. doi: 10.1074/jbc.M005304200.
We report the identification of a novel human cytokine, distantly related to interleukin (IL)-10, which we term IL-22. IL-22 is produced by activated T cells. IL-22 is a ligand for CRF2-4, a member of the class II cytokine receptor family. No high affinity ligand has yet been reported for this receptor, although it has been reported to serve as a second component in IL-10 signaling. A new member of the interferon receptor family, which we term IL-22R, functions as a second component together with CRF2-4 to enable IL-22 signaling. IL-22 does not bind the IL-10R. Cell lines were identified that respond to IL-22 by activation of STATs 1, 3, and 5, but were unresponsive to IL-10. In contrast to IL-10, IL-22 does not inhibit the production of proinflammatory cytokines by monocytes in response to LPS nor does it impact IL-10 function on monocytes, but it has modest inhibitory effects on IL-4 production from Th2 T cells.
我们报告鉴定出一种新型人类细胞因子，它与白细胞介素（IL）-10有较远的亲缘关系，我们将其命名为IL-22。IL-22由活化的T细胞产生。IL-22是II类细胞因子受体家族成员CRF2-4的配体。尽管据报道该受体在IL-10信号传导中作为第二组分发挥作用，但尚未有针对此受体的高亲和力配体的报道。我们将一种干扰素受体家族的新成员命名为IL-22R，它与CRF2-4一起作为第二组分，使IL-22能够进行信号传导。IL-22不与IL-10R结合。已鉴定出一些细胞系，它们通过激活信号转导和转录激活因子1、3和5对IL-22作出反应，但对IL-10无反应。与IL-10不同，IL-22既不抑制单核细胞对脂多糖反应产生促炎细胞因子，也不影响IL-10对单核细胞的功能，但它对Th2 T细胞产生IL-4有适度的抑制作用。
