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[Allopurinol-induced hypersensitivity syndrome resulting in death].

作者信息

Laurisch Sören, Jaedtke Maren, Demir Reyhan, Sorrentino Sajoscha A, Kielstein Jan T, Rennekampff Hans-Oliver, Vogt Peter M, Meyer Gerd P, Fuchs Martin, Klein Gunnar, Drexler Hartmut, Schieffer Bernhard, Napp L Christian

机构信息

Klinik für Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany.

出版信息

Med Klin (Munich). 2010 Apr;105(4):262-6. doi: 10.1007/s00063-010-1037-3.

DOI:10.1007/s00063-010-1037-3
PMID:20455046
Abstract

The present report describes the case of a 67-year-old patient who developed an allopurinol-induced hypersensitivity syndrome (AHS) with toxic epidermal necrolysis and subsequently died of septic multiorgan failure. Considering the increasing prescription rate of allopurinol, the present case report intends to demonstrate the underestimated threat of AHS.

摘要

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[Allopurinol-induced hypersensitivity syndrome resulting in death].
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2
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Stevens-Johnson syndrome, drug-induced hypersensitivity syndrome and toxic epidermal necrolysis caused by allopurinol in patients with a common HLA allele: what causes the diversity?具有常见人类白细胞抗原等位基因的患者中，别嘌醇引起的史蒂文斯-约翰逊综合征、药物性超敏反应综合征和中毒性表皮坏死松解症：多样性的成因是什么？
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[Fatal outcome in allopurinol hypersensitivity syndrome].[别嘌醇超敏综合征的致命结局]
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The prescription of allopurinol in a tertiary care centre: appropriate indications and dose adjustment.三级医疗中心别嘌醇的处方：恰当的适应症及剂量调整
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Acute compartment syndrome of the forearm as a rare complication of toxic epidermal necrolysis: a case report.

本文引用的文献

1
Allopurinol hypersensitivity syndrome: a preventable severe cutaneous adverse reaction?别嘌醇超敏综合征：一种可预防的严重皮肤不良反应？
Singapore Med J. 2008 May;49(5):384-7.
2
Allopurinol is the most common cause of Stevens-Johnson syndrome and toxic epidermal necrolysis in Europe and Israel.在欧洲和以色列，别嘌醇是史蒂文斯-约翰逊综合征和中毒性表皮坏死松解症最常见的病因。
J Am Acad Dermatol. 2008 Jan;58(1):25-32. doi: 10.1016/j.jaad.2007.08.036. Epub 2007 Oct 24.
3
Diagnosis and management of gout.痛风的诊断与管理
前臂急性筋膜室综合征作为中毒性表皮坏死松解症的罕见并发症：一例报告
J Med Case Rep. 2012 Mar 20;6:84. doi: 10.1186/1752-1947-6-84.
BMJ. 2006 Jun 3;332(7553):1315-9. doi: 10.1136/bmj.332.7553.1315.
4
Correction of allopurinol dosing should be based on clearance of creatinine, but not plasma creatinine levels: another insight to allopurinol-related toxicity.别嘌醇剂量的调整应基于肌酐清除率，而非血肌酐水平：对别嘌醇相关毒性的另一见解。
J Clin Rheumatol. 2005 Jun;11(3):129-33. doi: 10.1097/01.rhu.0000164822.98163.22.
5
Febuxostat compared with allopurinol in patients with hyperuricemia and gout.非布司他与别嘌醇治疗高尿酸血症和痛风患者的比较。
N Engl J Med. 2005 Dec 8;353(23):2450-61. doi: 10.1056/NEJMoa050373.
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Allopurinol-induced DRESS syndrome.别嘌醇诱发的药物超敏反应伴嗜酸性粒细胞增多和系统症状综合征。
Isr Med Assoc J. 2005 Oct;7(10):656-60.
7
HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol.HLA - B*5801等位基因作为别嘌醇引起严重皮肤不良反应的遗传标志物。
Proc Natl Acad Sci U S A. 2005 Mar 15;102(11):4134-9. doi: 10.1073/pnas.0409500102. Epub 2005 Mar 2.
8
Current management of gout in patients unresponsive or allergic to allopurinol.对别嘌醇无反应或过敏的痛风患者的当前管理方法。
Joint Bone Spine. 2004 Nov;71(6):481-5. doi: 10.1016/j.jbspin.2004.07.006.
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Clinical practice. Gout.临床实践。痛风。
N Engl J Med. 2003 Oct 23;349(17):1647-55. doi: 10.1056/NEJMcp030733.
10
Studies with the experimental antitumor agent 4-aminopyrazolo[3, 4-d]pyrimidine.关于实验性抗肿瘤药物4-氨基吡唑并[3,4-d]嘧啶的研究。
Cancer. 1960 May-Jun;13:482-9. doi: 10.1002/1097-0142(196005/06)13:3<482::aid-cncr2820130310>3.0.co;2-s.