癌胚抗原相关的细胞黏附分子

CEA-Related CAMs.

作者信息

Horst A K, Wagener C

机构信息

Institut für Klinische Chemie, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20251, Hamburg, Germany.

出版信息

Handb Exp Pharmacol. 2004(165):283-341. doi: 10.1007/978-3-540-68170-0_10.

DOI:10.1007/978-3-540-68170-0_10

PMID:20455097

Abstract

The carcinoembryonic antigen (CEA) family comprises a large number of cellular surface molecules, the CEA-related cell adhesion molecules (CEACAMs), which belong to the Ig superfamily. CEACAMs exhibit a complex expression pattern in normal and malignant tissues. The majority of the CEACAMs are cellular adhesion molecules that are involved in a great variety of distinct cellular processes, for example in the integration of cellular responses through homo- and heterophilic adhesion and interaction with a broad selection of signal regulatory proteins, i.e., integrins or cytoskeletal components and tyrosine kinases. Moreover, expression of CEACAMs affects tumor growth, angiogenesis, cellular differentiation, immune responses, and they serve as receptors for commensal and pathogenic microbes. Recently, new insights into CEACAM structure and function became available, providing further elucidation of their kaleidoscopic functions.

摘要

癌胚抗原（CEA）家族由大量细胞表面分子组成，即属于免疫球蛋白超家族的癌胚抗原相关细胞粘附分子（CEACAMs）。CEACAMs在正常组织和恶性组织中呈现复杂的表达模式。大多数CEACAMs是细胞粘附分子，参与多种不同的细胞过程，例如通过同型和异型粘附以及与多种信号调节蛋白（即整合素、细胞骨架成分和酪氨酸激酶）相互作用来整合细胞反应。此外，CEACAMs的表达会影响肿瘤生长、血管生成、细胞分化、免疫反应，并且它们还作为共生微生物和致病微生物的受体。最近，对CEACAM结构和功能有了新的认识，这进一步阐明了它们的多种功能。