Weng Chun-Yue, Hu Xin-Yi, Wang Ya-Jun
1The National and Local Joint Engineering Research Center for Biomanufacturing of Chiral Chemicals, Zhejiang University of Technology, Hangzhou, 310014 People's Republic of China.
2Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, 18 Chaowang Road, Hangzhou, 310014 People's Republic of China.
3 Biotech. 2020 Mar;10(3):132. doi: 10.1007/s13205-020-2122-9. Epub 2020 Feb 22.
Even though cell-cell adhesion molecule carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is extensively studied since the discovery, the role of CEACAM1 in different cancers is not completely clarified. In the present study, we examined CEACAM1 expression and its association with patient survival in various cancers by analysis of multiple databases. Oncomine database analysis revealed that CEACAM1 expression was upregulated in lung and pancreatic cancers, but downregulated in colorectal and head and neck cancers. PrognoScan and Kaplan‑Meier analyses showed that colorectal cancer patients as well as head and neck cancer patients with high CEACAM1 expression exhibited a higher overall survival rate. STRING analysis identified CEACAM3, CEACAM8, FN1, etc. as CEACAM1 interactors. Gene alteration analysis showed that CEACAM1 mutation predominantly occurred in the -terminal. Coexpression analysis demonstrated that CEACAM1 had distinct coexpressed genes in different cancers, but KRT protein was consistently coexpressed with CEACAM1 in diverse cancer types. All the observations supported that CEACAM1 can serve as a diagnostic marker for some cancers, such as pancreatic cancer. And high CEACAM1 expression provides a better prognosis for some cancers, such as colorectal and head and neck cancers.
尽管自发现以来细胞间粘附分子癌胚抗原相关细胞粘附分子1（CEACAM1）就受到了广泛研究，但其在不同癌症中的作用尚未完全阐明。在本研究中，我们通过分析多个数据库来检测CEACAM1的表达及其与各种癌症患者生存率的关联。Oncomine数据库分析显示，CEACAM1在肺癌和胰腺癌中表达上调，但在结直肠癌和头颈癌中表达下调。PrognoScan和Kaplan-Meier分析表明，CEACAM1高表达的结直肠癌患者以及头颈癌患者的总生存率更高。STRING分析确定CEACAM3、CEACAM8、FN1等为CEACAM1相互作用分子。基因改变分析表明，CEACAM1突变主要发生在N端。共表达分析表明，CEACAM1在不同癌症中有不同的共表达基因，但角蛋白（KRT）蛋白在多种癌症类型中均与CEACAM1持续共表达。所有这些观察结果支持CEACAM1可作为某些癌症（如胰腺癌）的诊断标志物。并且CEACAM1高表达为某些癌症（如结直肠癌和头颈癌）提供了更好的预后。
