Wikesjö U M, Claffey N, Egelberg J
School of Dentistry, Loma Linda University, CA.
J Clin Periodontol. 1991 Jan;18(1):60-4. doi: 10.1111/j.1600-051x.1991.tb01120.x.
Studies on periodontal repair to denuded root surfaces have suggested that initial clot adhesion to the root surface may be important for the nature of subsequent healing. To study this hypothesis, circumferential periodontal defects, approximately 5 mm in vertical dimensions, were surgically created and immediately treated around the mandibular premolars in 4 beagle dogs. Prior to wound closure, the root surfaces were treated with either the anticoagulant heparin or with saline. Tissue blocks were obtained at sacrifice 4 weeks after surgery. Histometric analysis showed that connective tissue repair to the root surface averaged 50% of the defect height for heparin-treated teeth as compared to 95% for saline-treated teeth. Junctional epithelium amounted to an average of 33% of the defect height in heparin-treated teeth in contrast to 5% following saline treatment. It can be concluded that heparin treatment of the root surface compromises connective tissue repair, confirming clot adhesion as one prerequisite for connective tissue repair of periodontal defects.
对裸露牙根表面进行牙周修复的研究表明，血凝块最初对牙根表面的黏附可能对后续愈合的性质很重要。为了研究这一假设，在4只比格犬的下颌前磨牙周围通过手术制造了垂直尺寸约为5毫米的环形牙周缺损，并立即进行处理。在伤口闭合前，牙根表面分别用抗凝剂肝素或生理盐水处理。术后4周处死动物时获取组织块。组织测量分析表明，肝素处理组牙齿牙根表面的结缔组织修复平均占缺损高度的50%，而生理盐水处理组为95%。在肝素处理的牙齿中，结合上皮平均占缺损高度的33%，而生理盐水处理后为5%。可以得出结论，牙根表面用肝素处理会损害结缔组织修复，这证实了血凝块黏附是牙周缺损结缔组织修复的一个先决条件。
