The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia 30332, USA.
Annu Rev Biomed Eng. 2010 Aug 15;12:345-67. doi: 10.1146/annurev-bioeng-070909-105339.
As the predominant cell type in blood, red blood cells (RBCs) and their biomechanical properties largely determine the rheological and hemodynamic behavior of blood in normal and disease states. In sickle cell disease (SCD), mechanically fragile, poorly deformable RBCs contribute to impaired blood flow and other pathophysiological aspects of the disease. The major underlying cause of this altered blood rheology and hemodynamics is hemoglobin S (HbS) polymerization and RBC sickling under deoxygenated conditions. This review discusses the characterization of the biomechanical properties of sickle RBCs and sickle blood as well as their implications toward a better understanding of the pathophysiology of the disease.
作为血液中的主要细胞类型，红细胞（RBC）及其生物力学特性在很大程度上决定了正常和疾病状态下血液的流变学和血液动力学特性。在镰状细胞病（SCD）中，机械脆弱、变形能力差的 RBC 导致血流受损和疾病的其他病理生理方面的问题。这种血液流变学和血液动力学改变的主要根本原因是脱氧条件下血红蛋白 S（HbS）聚合和 RBC 镰变。本综述讨论了镰状 RBC 和镰状血的生物力学特性的特征及其对更好地理解疾病病理生理学的意义。
