Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan.
Am J Reprod Immunol. 2010 Jun;63(6):601-10. doi: 10.1111/j.1600-0897.2010.00852.x. Epub 2010 Apr 23.
T-helper (Th) cells play a central role in modulating immune responses. The Th1/Th2 paradigm has now developed into the new Th1/Th2/Th17 paradigm. In addition to effector cells, Th cells are regulated by regulatory T (Treg) cells. Their capacity to produce cytokines is suppressed by immunoregulatory cytokines such as transforming growth factor (TGF)-beta and interleukin (IL)-10 or by cell-to-cell interaction. Here, we will review the immunological environment in normal pregnancy and complicated pregnancy, such as implantation failure, abortion, preterm labor, and preeclampsia from the viewpoint of the new Th1/Th2/Th17 and Treg paradigms.
辅助性 T 细胞（Th）在调节免疫反应中起着核心作用。Th1/Th2 范例现已发展为新的 Th1/Th2/Th17 范例。除了效应细胞外，Th 细胞还受到调节性 T（Treg）细胞的调节。它们产生细胞因子的能力受到免疫调节细胞因子（如转化生长因子-β和白细胞介素-10）或细胞间相互作用的抑制。在这里，我们将从新的 Th1/Th2/Th17 和 Treg 范例的角度回顾正常妊娠和复杂妊娠（如着床失败、流产、早产和子痫前期）的免疫学环境。
