Division of Evidence Based Medicine, Klinik für Dermatologie, Charité- Universitätsmedizin Berlin, Campus Charité Mitte, Charitéplatz, Berlin, Germany.
J Eur Acad Dermatol Venereol. 2010 Dec;24(12):1458-67. doi: 10.1111/j.1468-3083.2010.03671.x.
The development of evidence based guidelines is a demanding and time consuming process. Therefore it is important to share the knowledge and discuss the structure of these guidelines in detail.
To present a method report on the development process of the European evidence based guidelines on the systemic treatment of psoriasis vulgaris with the aim to offer guidance to other guidelines groups with lesser experience and to critically appraise the methodology of the guidelines development process.
The guidelines are based on the previously evaluated literature from three European national evidence based guidelines and an additional systematic search and evaluation of new literature. Further steps included a structured consensus conference and a DELPHI procedure to develop the recommendations, as well as several internal and external reviews. All steps were coordinated by the Division of evidence based medicine in cooperation with a group of methodologists.
A total of 114 studies were included, serving as base for the efficacy chapters of the intervention. The recommendations, based on the efficacy and the level of evidence of the included studies were discussed and finally consented by the guidelines group. After subsequent reviews the guidelines were presented to the European Dermatology Forum, European Academy of Dermatology and Venereology and Union Européenne des Médicins Spécialistes for approval and published in October 2009.
The development of European evidence based guidelines requires a coordinated structure which can be achieved by the integration of an experienced group of methodologists. Nevertheless further improvements are imaginable and might be considered for an update or other European evidence based guidelines.
制定基于证据的指南是一项要求高且耗时的过程。因此，分享知识并详细讨论这些指南的结构非常重要。
介绍制定欧洲基于证据的寻常型银屑病系统治疗指南的方法报告，旨在为经验较少的其他指南制定小组提供指导，并对指南制定过程的方法进行批判性评估。
这些指南基于先前评估的来自三个欧洲国家基于证据的指南以及另外一项针对新文献的系统搜索和评估的文献。进一步的步骤包括结构化共识会议和德尔菲程序以制定建议，以及多项内部和外部审查。所有步骤均由循证医学科与一组方法学家合作协调。
共有 114 项研究被纳入，作为干预措施的疗效章节的基础。基于纳入研究的疗效和证据水平，对建议进行了讨论，并最终由指南制定小组达成共识。随后经过几次审查，该指南提交给了欧洲皮肤病学会、欧洲皮肤病学会和欧洲皮肤科医生学会，以获得批准，并于 2009 年 10 月发表。
制定欧洲基于证据的指南需要协调一致的结构，这可以通过整合有经验的方法学家小组来实现。尽管如此，仍可以考虑进一步改进，以便更新或制定其他欧洲基于证据的指南。
