University of Madras-Department of Anatomy, Dr. Arcot Lakshmanasamy Mudaliar Postgraduate Institute of Basic Medical Sciences, Chennai, India.
J Sex Med. 2012 Dec;9(12):3066-78. doi: 10.1111/j.1743-6109.2010.01831.x. Epub 2010 Apr 26.
Sexual dysfunction is one of the major secondary complications in the diabetic. Mucuna pruriens, a leguminous plant identified for its antidiabetic, aphrodisiac, and improving fertility properties, has been the choice of Indian traditional medicine.
Objective of the present study was to analyze the efficacy of M. pruriens on male sexual behavior and sperm parameters in long-term hyperglycemic male rats.
Male albino rats were divided as group I control, group II diabetes induced (streptozotocin [STZ] 60 mg/kg of body weight (b.w.) in 0.1 M citrate buffer), group III diabetic rats administered with 200 mg/kg b.w. of ethanolic extract of M. pruriens seed, group IV diabetic rats administered with 5 mg/kg b.w. of sildenafil citrate (SC), group V administered with 200 mg/kg b.w. of extract, and group VI administered with 5 mg/kg b.w. of SC. M. pruriens and SC were administered in single oral dosage per day for a period of 60 days. The animals were subjected to mating behavior analyses, libido, test of potency, and epididymal sperms were analyzed.
The mating behavior, libido, test of potency, along with epididymal sperms were studied.
The study showed significant reduction in sexual behavior and sperm parameters in group II. Daily sperm production (DSP) and levels of follicular stimulating hormone, luteinizing hormone, and testosterone were significantly reduced in group II, whereas the animals with diabetes administered with seed extract of M. pruriens (group III) showed significant improvement in sexual behavior, libido and potency, sperm parameters, DSP, and hormonal levels when compared to group II.
The present work reveals the potential efficacy of ethanolic seed extract of M. pruriens to improve male sexual behavior with androgenic and antidiabetic effects in the STZ-induced diabetic male rats. This study supports the usage of M. pruriens in the Indian system of medicine as sexual invigorator in diabetic condition and encourages performing similar study in men.
性功能障碍是糖尿病的主要继发性并发症之一。Mucuna pruriens 是一种豆科植物，具有抗糖尿病、壮阳和提高生育能力的特性，一直是印度传统医学的选择。
本研究旨在分析 M. pruriens 对长期高血糖雄性大鼠的雄性性行为和精子参数的疗效。
雄性白化大鼠分为 I 组对照组、II 组糖尿病诱导（链脲佐菌素[STZ]60mg/kg 体重[BW]于 0.1M 柠檬酸盐缓冲液）、III 组糖尿病大鼠给予 200mg/kg BW 的 M. pruriens 种子乙醇提取物、IV 组糖尿病大鼠给予 5mg/kg BW 的西地那非 citrate（SC）、V 组给予 200mg/kg BW 的提取物，和 VI 组给予 5mg/kg BW 的 SC。M. pruriens 和 SC 每天口服一次，共 60 天。对动物进行交配行为分析、性欲、效力测试和附睾精子进行分析。
研究了交配行为、性欲、效力测试以及附睾精子。
研究表明，II 组的性行为和精子参数显著减少。与 II 组相比，II 组的每日精子产量（DSP）和卵泡刺激素、黄体生成素和睾酮水平显著降低，而糖尿病动物给予 M. pruriens 种子提取物（III 组）的性行为、性欲和效力、精子参数、DSP 和激素水平显著改善。
本工作揭示了 M. pruriens 乙醇种子提取物在 STZ 诱导的糖尿病雄性大鼠中具有改善雄性性行为和雄激素及抗糖尿病作用的潜力。这项研究支持在印度医学体系中使用 M. pruriens 作为糖尿病患者的性兴奋剂，并鼓励在男性中进行类似的研究。
