Faculty of Pharmaceutical Sciences, Jodhpur National University, Jodhpur, Rajasthan, India.
J Ethnopharmacol. 2013 Jun 21;148(1):210-7. doi: 10.1016/j.jep.2013.04.011. Epub 2013 Apr 21.
Corchorus depressus Linn. has been used as an aphrodisiac in traditional Indian medicine to treat male sexual dysfunction and impotency.
The petroleum ether, chloroform, ethyl acetate, n-butanol and aqueous fractions of 95% methanol extract of Corchorus depressus were screened initially for their in vitro aphrodisiac activity on rabbit corpus cavernosum smooth muscle. The chloroform fraction (CDC) was found to be the most active and therefore investigated further on general mating behavior, libido and potency of normal male Wistar albino rats in comparison with the standard drug, Sildenafil citrate.
Animals were divided into the following groups: Control, SC CDC 100, CDC 200, and CDC 400, who received saline, Sildenafil citrate or the chloroform fraction of Corchorus depressus at doses of 100, 200 or 400mg/kg b.wt., respectively. The route of administration for all the groups was oral dosing, which was once in a day for 45 days. To analyze the mating behavior, female rats with estrus phase were used.
The chloroform fraction of methanolic extract of Corchorus depressus significantly reduced ML, IL, PEI and III. There was a significant increase in the MF, IF and EL and serum testosterone levels throughout the study period. The potency test significantly increased erections, quick flips, long flips and total reflex. In vitro aphrodisiac activity was significantly higher in chloroform fraction at a concentration of 25.0mg/ml, which induced 71.4% relaxation. The combined results of the above mentioned models indicate that the chloroform fraction of Corchorus depressus produces a significant increase in sexual activity as exhibited by 25mg/ml in vitro and 400mg/kg in vivo. In comparison with the control, all the drug-treated groups have shown drug-induced effects for a few parameters.
In vitro and in vivo studies provide valuable experimental evidence that the chloroform fraction of methanolic extract of Corchorus depressus possesses aphrodisiac property. This study further substantiates the ethnopharmacological claims of Corchorus depressus as a sexual stimulating agent and offers a significant potential for studying the effect on male sexual response and its dysfunctions.
黄麻已被传统印度医学用作壮阳药，用于治疗男性性功能障碍和阳痿。
初步筛选 95%甲醇提取物的石油醚、氯仿、乙酸乙酯、正丁醇和水相部分对兔阴茎海绵体平滑肌的体外壮阳活性。发现氯仿部分（CDC）最活跃，因此与标准药物西地那非柠檬酸盐进行比较，进一步研究其对正常雄性 Wistar 白化大鼠的一般交配行为、性欲和效力。
动物分为以下几组：对照组、SC CDC 100、CDC 200 和 CDC 400，分别给予生理盐水、西地那非柠檬酸盐或黄麻氯仿部分，剂量为 100、200 或 400mg/kg 体重。所有组的给药途径均为口服，每天一次，共 45 天。为了分析交配行为，使用处于发情期的雌性大鼠。
黄麻甲醇提取物的氯仿部分显著降低了 ML、IL、PEI 和 III。在整个研究期间，MF、IF 和 EL 以及血清睾酮水平均显著增加。效力测试显著增加勃起、快速翻转、长翻转和总反射。在浓度为 25.0mg/ml 时，氯仿部分的体外壮阳活性显著较高，诱导 71.4%的松弛。上述模型的综合结果表明，氯仿部分的黄麻产生显著增加性活动，在体外 25mg/ml 和体内 400mg/kg 下表现出这种作用。与对照组相比，所有药物治疗组在几个参数上都表现出药物诱导的作用。
体内外研究提供了有价值的实验证据，证明黄麻甲醇提取物的氯仿部分具有壮阳作用。这项研究进一步证实了黄麻作为性刺激剂的民族药理学说法，并为研究其对男性性反应及其功能障碍的影响提供了重要潜力。
