Department of Clinical and Experimental Medicine, Padua University School of Medicine, 35128 Padua, Italy.
Respir Med. 2010 Jul;104 Suppl 1:S86-91. doi: 10.1016/j.rmed.2010.03.022. Epub 2010 Apr 24.
A number of recently published results have suggested the possibility of using stem cells to regenerate lung tissue. Several groups have developed various animal models employing haematopoietic stem cells, mesenchymal and endothelial progenitors, and embryonic cells, in which it has been possible to ameliorate the diseased lung. Despite these stimulating in vivo results a number of questions are pending before stem cell derivatives can be used in human lung disorders. This brief review will examine encouraging data that suggest the possibility of using stem cells in the therapy of lung diseases. In parallel, controversial findings are reviewed indicating that caution should be recommended before proposing to utilize stem cells in human lung diseases.
许多最近发表的研究结果表明，使用干细胞来再生肺组织是可能的。一些研究小组开发了各种动物模型，采用造血干细胞、间充质和内皮祖细胞以及胚胎细胞，这些模型已经能够改善患病的肺部。尽管这些体内研究结果令人振奋，但在干细胞衍生物可用于人类肺部疾病之前，仍有许多问题需要解决。这篇简短的综述将检查有希望的数据，这些数据表明在肺部疾病的治疗中使用干细胞是可能的。同时，还回顾了有争议的发现，这些发现表明，在提出将干细胞用于人类肺部疾病之前，应该谨慎。
