Yen C C, Yang S H, Lin C Y, Chen C M
Department of Life Sciences, National Chung Hsing University, and Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.
Eur J Clin Invest. 2006 May;36(5):310-9. doi: 10.1111/j.1365-2362.2006.01638.x.
Until recently, it was thought that only embryonic stem cells were pluripotent and that adult stem cells were restricted in their differentiative and regenerative potential to become the tissues in which they reside. However, the discovery that adult stem cells in one tissue can contribute to the formation of other tissues, especially after injury or cell damage, implies that stem cells have developmental plasticity. For example, haematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs) from bone marrow can be used to regenerate diverse tissues at distant sites, including the lung. This article reviews the character of stem cells in the lung parenchyma and focuses on the potential uses of adult stem cells in research of lung injury and lung disease therapies.
直到最近，人们一直认为只有胚胎干细胞具有多能性，而成体干细胞在分化和再生潜力方面受到限制，只能形成它们所在的组织。然而，有发现表明，一个组织中的成体干细胞能够促成其他组织的形成，尤其是在损伤或细胞受损后，这意味着干细胞具有发育可塑性。例如，来自骨髓的造血干细胞（HSC）和间充质干细胞（MSC）可用于在远处部位再生多种组织，包括肺。本文综述了肺实质中干细胞的特性，并重点关注成体干细胞在肺损伤研究和肺病治疗中的潜在用途。
