Faculty of Health Sciences, Oslo University College, Norway, Norway.
Forensic Sci Int Genet. 2010 Jul;4(4):e101-3. doi: 10.1016/j.fsigen.2009.08.011. Epub 2009 Sep 19.
We present allele frequencies and statistical parameters of forensic interest for 10 autosomal STR loci and 12 Y-STR loci obtained from an Icelandic population sample. The testing of the STR loci in the AmpFlSTR SGM Plus kit in 151 unrelated individuals showed heterozygosity frequencies ranging from 0.775 (vWA) to 0.874 (D2S1338). A significant deviation from Hardy-Weinberg equilibrium was observed in vWA, but it was not statistically significant after application of Bonferroni correction. The exact test of differentiation analysis revealed one significant departure from differentiation out of 45 pairwise comparisons, but the departure was not significant after Bonferroni's correction. Seventy-five different haplotypes were observed in the 100 male samples analysed for the twelve Y-STRs included in the PowerPlex Y-system. No haplotype was observed more than four times. Pairwise comparisons for genetic distances based on the minimal haplotype diversity showed Iceland to be closer to Norway and Denmark than to Sweden, UK, Ireland and Greenland. As expected, the higher percentage of variation was observed within than among populations (90.40% versus 9.60%, respectively, for R(ST)).
我们呈现了来自冰岛人群样本的 10 个常染色体 STR 基因座和 12 个 Y-STR 基因座的等位基因频率和具有法医学意义的统计参数。在 151 名无关个体中使用 AmpFlSTR SGM Plus 试剂盒检测 STR 基因座，杂合度频率范围从 0.775（vWA）到 0.874（D2S1338）。在 vWA 中观察到与 Hardy-Weinberg 平衡显著偏离，但在应用 Bonferroni 校正后，这种偏离并不具有统计学意义。分化分析的精确检验显示，在 45 对两两比较中有一个显著的偏离，但在 Bonferroni 校正后，这种偏离并不显著。在所分析的 100 个男性样本中，观察到了 12 个 Y-STR 中的 75 种不同单倍型。没有观察到超过 4 次的单倍型。基于最小单倍型多样性的遗传距离的成对比较显示，冰岛与挪威和丹麦的关系比与瑞典、英国、爱尔兰和格陵兰更为密切。正如预期的那样，群体内的变异百分比高于群体间（分别为 90.40%和 9.60%，用于 R(ST)）。
