中国东部浙江省汉族人群 17 个 Y-STR 基因座的群体遗传学研究。
Population genetics of 17 Y-STR loci in a large Chinese Han population from Zhejiang Province, Eastern China.
机构信息
Department of Criminal Investigation of Zhejiang Provincial Public Security Bureau, Hangzhou, China.
出版信息
Forensic Sci Int Genet. 2011 Jan;5(1):e11-3. doi: 10.1016/j.fsigen.2009.12.005. Epub 2010 Jan 19.
Seventeen Y-STRs (DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS385a, DYS385b, DYS438, DYS439, DYS437, DYS448, DYS456, DYS458, DYS635 and YGATAH4) were analyzed for 4451 Chinese Han unrelated males from Zhejiang Province, Eastern China, with the AmpFlSTR Yfiler™ PCR Amplification kit. A total of 3389 different haplotypes was identified, of which 2877 were unique and 512 repeatedly found among different individuals. The overall haplotype diversity (HD) and discrimination capacity (DC) were 0.999696 and 0.761402, respectively. Analysis of molecular variance (AMOVA) tests demonstrated that genetic distance between Zhejiang Han and most Chinese Han populations is closer than that between Zhejiang Han and non-Han populations. This study provides information for the application of Y-chromosomal STRs to forensic identification, indicating that the extended genotyping of Y-STRs is needed for forensic practice.
对来自中国东部浙江省的 4451 名无关汉族男性进行了 17 个 Y-STR（DYS19、DYS389I、DYS389II、DYS390、DYS391、DYS392、DYS393、DYS385a、DYS385b、DYS438、DYS439、DYS437、DYS448、DYS456、DYS458、DYS635 和 YGATAH4）分析，使用 AmpFlSTR Yfiler™ PCR 扩增试剂盒。共鉴定出 3389 种不同的单倍型，其中 2877 种是独特的，512 种在不同个体中重复出现。总体单倍型多样性（HD）和鉴别能力（DC）分别为 0.999696 和 0.761402。分子方差分析（AMOVA）测试表明，浙江汉族与大多数中国汉族人群之间的遗传距离比浙江汉族与非汉族人群之间的更近。这项研究为 Y 染色体 STR 在中国法医学鉴定中的应用提供了信息，表明法医学实践需要对 Y-STR 进行扩展基因分型。
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