中国湖南省汉族人群26个Y染色体短串联重复序列位点的群体遗传学研究
Population genetics of 26 Y-STR loci for the Han ethnic in Hunan province, China.
作者信息
Jiang Weibo, Gong Zheng, Rong Haibo, Guan Hua, Zhang Tao, Zhao Yihe, Fu Xiaoliang, Zha Lagabaiyila, Jin Chuan, Ding Yanjun
机构信息
The First Research Institute, Ministry of Public Security of P.R.C, Capital Gymnasium South Road 1, Beijing, 100037, China.
Criminal Technology Squad, Harbin Public Security Bureau, Harbin, 150010, Heilongjiang, China.
出版信息
Int J Legal Med. 2017 Jan;131(1):115-117. doi: 10.1007/s00414-016-1411-7. Epub 2016 Jul 23.
To study the population data of Y-chromosome STRs (Y-STRs) of Han population resided in Hunan province, we analyzed haplotypes of 26 Y-STRs (DYS19, DYS385a/b, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS437, DYS438, DYS439, DYS448, DYS456, DYS458, DYS481, DYS533, DYS549, DYS570, DYS576, DYS635, DYS643, DYS388, DYS449, DYS460, and YGATAH4) in 310 unrelated male individuals using a commercially available Goldeneye® DNA ID 26Y system. The calculated average gene diversity values ranged from 0.4211 to 0.9590 for DYS438 and DYS385a/b loci, respectively. The discriminatory capacity was 96.77 % with 300 observed haplotypes. Population relationships between Hunan Han and eight other populations available from Y-chromosome haplotype reference database (YHRD) were compared. The results showed that the Han population resided in the Hunan district is significantly different from other populations. Our results also indicated that these 26 Y-STR loci were highly genetically polymorphic in the Hunan Han population and of great value in forensic application.
为研究居住在湖南省的汉族人群Y染色体短串联重复序列（Y-STRs）的群体数据，我们使用市售的Goldeneye® DNA ID 26Y系统分析了310名无关男性个体中26个Y-STRs（DYS19、DYS385a/b、DYS389I、DYS389II、DYS390、DYS391、DYS392、DYS393、DYS437、DYS438、DYS439、DYS448、DYS456、DYS458、DYS481、DYS533、DYS549、DYS570、DYS576、DYS635、DYS643、DYS388、DYS449、DYS460和YGATAH4）的单倍型。DYS438和DYS385a/b位点计算出的平均基因多样性值分别为0.4211至0.9590。观察到300种单倍型，其鉴别能力为96.77%。比较了湖南汉族与Y染色体单倍型参考数据库（YHRD）中其他八个群体之间的群体关系。结果表明，居住在湖南地区的汉族人群与其他群体有显著差异。我们的结果还表明，这26个Y-STR位点在湖南汉族人群中具有高度的遗传多态性，在法医学应用中具有重要价值。
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