Department of Pediatrics, Aarhus University Hospital, Skejby, 8200 Arhus N, Denmark.
J Cyst Fibros. 2010 Jul;9(4):257-62. doi: 10.1016/j.jcf.2010.03.011. Epub 2010 May 8.
Cystic fibrosis (CF) affects the lungs causing infections and inflammation. Surfactant protein D (SP-D) is an innate defense lectin primarily secreted in the lungs. We investigated the influence of the SP-D Met11Thr polymorphism on CF lung function; and serum SP-D as a marker for CF lung disease.
For 107 CF patients (73 children, and 34 adults) serum SP-D and SP-D Met11Thr genotype were available. Leukocyte count was obtained for a subset of patients. Lung function was measured as forced expiratory volume in one second (FEV-1).
Serum SP-D was increased in CF patients compared to healthy controls, positively correlated to leukocyte count, and negatively correlated to FEV-1. We found no correlation between SP-D Met11Thr genotype and FEV-1, and we found corresponding genotype frequencies in CF patients and in healthy controls.
Serum SP-D in CF patients was increased in parallel with leukocyte count and with reduced FEV-1 and may constitute an alternative biomarker for lung disease, in the clinical setting and in research.
囊性纤维化（CF）会影响肺部，导致感染和炎症。表面活性蛋白 D（SP-D）是一种主要在肺部分泌的先天防御凝集素。我们研究了 SP-D Met11Thr 多态性对 CF 肺功能的影响；以及血清 SP-D 作为 CF 肺疾病的标志物。
我们对 107 名 CF 患者（73 名儿童和 34 名成人）的血清 SP-D 和 SP-D Met11Thr 基因型进行了检测。还对一部分患者进行了白细胞计数。肺功能通过一秒用力呼气量（FEV-1）来测量。
与健康对照组相比，CF 患者的血清 SP-D 升高，与白细胞计数呈正相关，与 FEV-1 呈负相关。我们发现 SP-D Met11Thr 基因型与 FEV-1 之间没有相关性，并且在 CF 患者和健康对照组中发现了相应的基因型频率。
CF 患者的血清 SP-D 与白细胞计数平行升高，与 FEV-1 降低相关，可能是临床和研究中肺疾病的替代生物标志物。
