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本文引用的文献

1
Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies.肾损伤分子-1 在临床前生物标志物资格研究中优于传统的肾损伤生物标志物。
Nat Biotechnol. 2010 May;28(5):478-85. doi: 10.1038/nbt.1623.
2
Renal biomarker qualification submission: a dialog between the FDA-EMEA and Predictive Safety Testing Consortium.肾脏生物标志物资格申报：FDA-EMEA 与预测性安全检测联盟之间的对话。
Nat Biotechnol. 2010 May;28(5):455-62. doi: 10.1038/nbt.1625. Epub 2010 May 10.
3
Renal vulnerability to drug toxicity.肾脏对药物毒性的易感性。
Clin J Am Soc Nephrol. 2009 Jul;4(7):1275-83. doi: 10.2215/CJN.02050309. Epub 2009 Jun 11.
4
Creatinine kinetics and the definition of acute kidney injury.肌酐动力学与急性肾损伤的定义
J Am Soc Nephrol. 2009 Mar;20(3):672-9. doi: 10.1681/ASN.2008070669. Epub 2009 Feb 25.
5
Biomarkers of nephrotoxic acute kidney injury.肾毒性急性肾损伤的生物标志物
Toxicology. 2008 Mar 20;245(3):182-93. doi: 10.1016/j.tox.2007.12.024. Epub 2008 Jan 4.
6
Biomarkers of acute kidney injury.急性肾损伤的生物标志物
Annu Rev Pharmacol Toxicol. 2008;48:463-93. doi: 10.1146/annurev.pharmtox.48.113006.094615.
7
Improving outcomes from acute kidney injury.改善急性肾损伤的治疗效果。
J Am Soc Nephrol. 2007 Jul;18(7):1992-4. doi: 10.1681/ASN.2007050567.
8
Acute kidney injury, mortality, length of stay, and costs in hospitalized patients.住院患者的急性肾损伤、死亡率、住院时间及费用
J Am Soc Nephrol. 2005 Nov;16(11):3365-70. doi: 10.1681/ASN.2004090740. Epub 2005 Sep 21.
9
Nephrotoxicity of over-the-counter analgesics, natural medicines, and illicit drugs.非处方镇痛药、天然药物和非法药物的肾毒性。
Adolesc Med Clin. 2005 Feb;16(1):31-43, x. doi: 10.1016/j.admecli.2004.10.001.
10
Spectrum of acute renal failure in the intensive care unit: the PICARD experience.重症监护病房急性肾衰竭的范围：PICARD研究经验
Kidney Int. 2004 Oct;66(4):1613-21. doi: 10.1111/j.1523-1755.2004.00927.x.

用于检测肾毒性的下一代生物标志物。

Next-generation biomarkers for detecting kidney toxicity.

机构信息

Renal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

出版信息

Nat Biotechnol. 2010 May;28(5):436-40. doi: 10.1038/nbt0510-436.

DOI:10.1038/nbt0510-436
PMID:20458311
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3033582/
Abstract

There is a paucity of biomarkers that reliably detect nephrotoxicity. The Predictive Safety Testing Consortium (PSTC) faced several challenges in identifying novel safety biomarkers in the renal setting.

摘要

目前可靠地检测肾毒性的生物标志物较少。预测安全测试联盟（PSTC）在确定肾脏环境中的新型安全生物标志物方面面临着一些挑战。