特异性 DNA 序列中 N6-甲基腺嘌呤的鉴别。
Discrimination of N6-methyl adenine in a specific DNA sequence.
机构信息
The Institute of Scientific and Industrial Research (ISIR), Osaka University, Ibaraki 567-0047, Japan.
出版信息
Chem Commun (Camb). 2010 Aug 14;46(30):5530-2. doi: 10.1039/c0cc00172d. Epub 2010 May 11.
PMID:20458423
Abstract
We have developed a novel chemistry-based method to detect adenine methylation. A DNA probe functionalized with a formyl group discriminates between adenine and N6-methyl adenine by the formation of a selective interstrand cross-link.
摘要
我们开发了一种新的基于化学的方法来检测腺嘌呤甲基化。一个带有甲酰基的 DNA 探针通过形成选择性的链间交联来区分腺嘌呤和 N6-甲基腺嘌呤。
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