Mental Health Problems and Substance Abuse Services Unit, National Institute for Health and Welfare, P.O. Box 30, 00271 Helsinki, Finland.
Soc Psychiatry Psychiatr Epidemiol. 2011 Jul;46(7):623-33. doi: 10.1007/s00127-010-0228-9. Epub 2010 May 11.
To examine whether partner's psychiatric and somatic disorders are risk factors for incidence of psychiatric disorders among non-psychiatric individuals at baseline.
Register-based 6-year follow-up on Finns (106,935 men and 96,024 women aged 40 and over), living with a married or cohabiting partner at the end of 1997. The outcome measures included non-psychotic major depressive disorder (MDD), substance use disorder (SUD), and severe psychiatric disorder, evaluated using information on reimbursement for drug costs, purchases of prescription medication, and principal causes of hospitalization.
Among persons whose partner had any psychiatric disorder, the incidence rate ratio (IRR) for own MDD, controlling for own age at baseline, was 1.58 (95% confidence interval 1.48-1.69) in men, and 1.58 (1.48-1.69) in women. Among persons whose partner had somatic hospitalization, the IRR for own MDD was 1.14 (1.08-1.20) in men and 1.20 (1.15-1.25) in women. Among both men and women, the highest risk for incidence of own MDD was among persons whose partner had both MDD and SUD (IRR 2.65, 1.67-4.21 and IRR 2.13, 1.62-2.80, respectively). Further adjustment for sociodemographic and union characteristics had little effect on the associations.
In married and cohabiting couples, partner's somatic and particularly psychiatric morbidity associate with psychiatric disorders in non-psychiatric subjects, independent of sociodemographic and union characteristics. The healthy spouse's care burden is a potential point of intervention in order to prevent new psychiatric morbidity, but also to provide the mentally ill first partner a chance to recover in a supportive family environment.
探讨配偶的精神和躯体障碍是否是基线时无精神障碍个体发生精神障碍的危险因素。
对芬兰人（1997 年末已婚或同居的 106935 名男性和 96024 名 40 岁及以上的女性）进行了基于登记的 6 年随访。结局指标包括非精神病性重性抑郁障碍（MDD）、物质使用障碍（SUD）和严重精神障碍，通过药物费用报销、处方药购买和主要住院原因的信息进行评估。
在配偶有任何精神障碍的人中，自身 MDD 的发病率比（IRR），控制自身基线年龄，男性为 1.58（95%置信区间 1.48-1.69），女性为 1.58（1.48-1.69）。在配偶有躯体住院的人中，自身 MDD 的 IRR 男性为 1.14（1.08-1.20），女性为 1.20（1.15-1.25）。在男性和女性中，自身 MDD 发病率最高的是配偶既有 MDD 又有 SUD 的人（IRR 分别为 2.65，1.67-4.21 和 IRR 为 2.13，1.62-2.80）。进一步调整社会人口学和婚姻特征对这些关联影响不大。
在已婚和同居的夫妇中，配偶的躯体和特别是精神疾病与非精神科患者的精神障碍有关，独立于社会人口学和婚姻特征。健康配偶的照顾负担是一个潜在的干预点，以防止新的精神疾病，也为患有精神疾病的第一配偶在支持性家庭环境中恢复提供机会。
