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脊椎动物中 Notch 信号/靶基因的非经典激活。

Non-canonical activation of Notch signaling/target genes in vertebrates.

机构信息

Neuro-Stem Cell Biology Laboratory, Neurobiology Division, Rajiv Gandhi Centre for Biotechnology, Thycaud PO, Poojappura, Thiruvananthapuram, 695 014, Kerala, India.

出版信息

Cell Mol Life Sci. 2010 Sep;67(17):2957-68. doi: 10.1007/s00018-010-0391-x. Epub 2010 May 11.

DOI:10.1007/s00018-010-0391-x
PMID:20458516
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11115867/
Abstract

Evolutionarily conserved Notch signaling orchestrates diverse physiological mechanisms during metazoan development and homeostasis. Classically, ligand-activated Notch receptors transduce the signaling cascade through the interaction of DNA-bound CBF1-co-repressor complex. However, recent reports have demonstrated execution of a CBF1-independent Notch pathway through signaling cross-talks in various cells/tissues. Here, we have tried to congregate the reports that describe the non-canonical/CBF1-independent Notch signaling and target gene activation in vertebrates with specific emphasis on their functional relevance.

摘要

进化保守的 Notch 信号通路在后生动物的发育和稳态过程中协调多种生理机制。经典地，配体激活的 Notch 受体通过 DNA 结合的 CBF1 共抑制复合物的相互作用转导信号级联。然而，最近的报道表明，在各种细胞/组织中通过信号串扰执行了一种不依赖于 CBF1 的 Notch 途径。在这里，我们试图汇集描述脊椎动物中非经典/不依赖于 CBF1 的 Notch 信号和靶基因激活的报告，并特别强调它们的功能相关性。

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本文引用的文献

1
ATF2 maintains a subset of neural progenitors through CBF1/Notch independent Hes-1 expression and synergistically activates the expression of Hes-1 in Notch-dependent neural progenitors.ATF2 通过 CBF1/Notch 独立的 Hes-1 表达维持一组神经祖细胞，并协同激活 Notch 依赖性神经祖细胞中 Hes-1 的表达。
J Neurochem. 2010 May;113(4):807-18. doi: 10.1111/j.1471-4159.2010.06574.x. Epub 2010 Jan 8.
2
Notch independent signalling mediates Schwann cell-like differentiation of adipose derived stem cells.Notch 独立信号转导介导脂肪来源干细胞向雪旺细胞样分化。
Neurosci Lett. 2009 Dec 25;467(2):164-8. doi: 10.1016/j.neulet.2009.10.030. Epub 2009 Oct 13.
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Targeting Notch signaling in pancreatic cancer patients--rationale for new therapy.针对胰腺癌患者的 Notch 信号通路——新疗法的原理。
Adv Med Sci. 2009;54(2):136-42. doi: 10.2478/v10039-009-0026-3.
4
Epithelial transformation by KLF4 requires Notch1 but not canonical Notch1 signaling.KLF4 通过 Notch1 但不通过经典 Notch1 信号通路实现上皮细胞的转化。
Cancer Biol Ther. 2009 Oct;8(19):1840-51. doi: 10.4161/cbt.8.19.9440.
5
Ligand-independent traffic of Notch buffers activated Armadillo in Drosophila.Notch的不依赖配体的转运调节果蝇中被激活的犰狳蛋白。
PLoS Biol. 2009 Aug;7(8):e1000169. doi: 10.1371/journal.pbio.1000169. Epub 2009 Aug 11.
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Hairy1 acts as a node downstream of Wnt signaling to maintain retinal stem cell-like progenitor cells in the chick ciliary marginal zone.Hairy1作为Wnt信号下游的一个节点，维持鸡睫状边缘区的视网膜干细胞样祖细胞。
Development. 2009 Jun;136(11):1823-33. doi: 10.1242/dev.029272. Epub 2009 Apr 22.
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The canonical Notch signaling pathway: unfolding the activation mechanism.经典Notch信号通路：揭示激活机制
Cell. 2009 Apr 17;137(2):216-33. doi: 10.1016/j.cell.2009.03.045.
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A hierarchical cascade activated by non-canonical Notch signaling and the mTOR-Rictor complex regulates neglect-induced death in mammalian cells.由非经典Notch信号和mTOR-Rictor复合体激活的分级联反应调节哺乳动物细胞中忽视诱导的死亡。
Cell Death Differ. 2009 Jun;16(6):879-89. doi: 10.1038/cdd.2009.20. Epub 2009 Mar 6.
10
Committed neuronal precursors confer astrocytic potential on residual neural precursor cells.定向神经前体细胞赋予残余神经前体细胞星形胶质细胞分化潜能。
Dev Cell. 2009 Feb;16(2):245-55. doi: 10.1016/j.devcel.2008.12.014.