脊椎动物中 Notch 信号/靶基因的非经典激活。
Non-canonical activation of Notch signaling/target genes in vertebrates.
机构信息
Neuro-Stem Cell Biology Laboratory, Neurobiology Division, Rajiv Gandhi Centre for Biotechnology, Thycaud PO, Poojappura, Thiruvananthapuram, 695 014, Kerala, India.
出版信息
Cell Mol Life Sci. 2010 Sep;67(17):2957-68. doi: 10.1007/s00018-010-0391-x. Epub 2010 May 11.
Abstract
Evolutionarily conserved Notch signaling orchestrates diverse physiological mechanisms during metazoan development and homeostasis. Classically, ligand-activated Notch receptors transduce the signaling cascade through the interaction of DNA-bound CBF1-co-repressor complex. However, recent reports have demonstrated execution of a CBF1-independent Notch pathway through signaling cross-talks in various cells/tissues. Here, we have tried to congregate the reports that describe the non-canonical/CBF1-independent Notch signaling and target gene activation in vertebrates with specific emphasis on their functional relevance.
摘要
进化保守的 Notch 信号通路在后生动物的发育和稳态过程中协调多种生理机制。经典地，配体激活的 Notch 受体通过 DNA 结合的 CBF1 共抑制复合物的相互作用转导信号级联。然而，最近的报道表明，在各种细胞/组织中通过信号串扰执行了一种不依赖于 CBF1 的 Notch 途径。在这里，我们试图汇集描述脊椎动物中非经典/不依赖于 CBF1 的 Notch 信号和靶基因激活的报告，并特别强调它们的功能相关性。
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