Department of Chemistry, Annamalai University, Annamalai nagar, 608 002, Tamilnadu, India.
J Fluoresc. 2010 Nov;20(6):1199-210. doi: 10.1007/s10895-010-0669-2. Epub 2010 May 11.
The absorption and fluorescence spectra of imipramine and carbamazepine have been recorded in solvents of different polarity and β-cyclodextrin (β-CD). The inclusion complexes for both drugs are investigated by UV-visible, fluorimetry and DFT. Solvents study shows isotropic polarizability structure is present in imipramine while the amide group inhibits the above structure in carbamazepine. The band width half a maximum of carbamazepine decreased in polar solvents suggest that different species present in non-polar solvents and among that one of this species is affected in protic solvents. Both drugs form two different 1:2 inclusion complexes with β-CD. The structured longer wavelength emission in β-CD solution suggests viscosity plays major roles in the inclusion complex. This study also confirms van der Waals forces and hydrophobic interactions are the driving forces in imipramine and hydrogen bonding interactions play major roles in carbamazepine.
丙咪嗪和卡马西平在不同极性溶剂和β-环糊精（β-CD）中的吸收和荧光光谱已经被记录下来。通过紫外可见分光光度法、荧光法和密度泛函理论研究了这两种药物的包合物。溶剂研究表明，丙咪嗪具有各向同性极化结构，而酰胺基团抑制了卡马西平的上述结构。在极性溶剂中，卡马西平的带宽半最大值减小表明，非极性溶剂中存在不同的物种，其中一种在质子溶剂中受到影响。这两种药物都与β-CD 形成两种不同的 1:2 包合物。β-CD 溶液中结构较长波长的发射表明，粘度在包合物中起主要作用。这项研究还证实，范德华力和疏水相互作用是丙咪嗪的驱动力，氢键相互作用在卡马西平的作用中起着主要作用。
