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The use of biorelevant dissolution media to forecast the in vivo performance of a drug.
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Current methods for predicting human food effect.
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Mechanistic Investigation into the Phase Separation Behavior of Soluplus in the Presence of Biorelevant Media.
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Evaluation of bioaccessibility, metabolic clearance and interaction with xenobiotic receptors (PXR and AhR) of cinnamaldehyde.
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A standardized mini paddle apparatus as an alternative to the standard paddle.
AAPS PharmSciTech. 2008;9(4):1179-84. doi: 10.1208/s12249-008-9161-6. Epub 2008 Nov 25.
2
Dissolution media simulating conditions in the proximal human gastrointestinal tract: an update.
Pharm Res. 2008 Jul;25(7):1663-76. doi: 10.1007/s11095-008-9569-4. Epub 2008 Apr 11.
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When poor solubility becomes an issue: from early stage to proof of concept.
Eur J Pharm Sci. 2007 Aug;31(5):249-61. doi: 10.1016/j.ejps.2007.05.110. Epub 2007 May 21.
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Estimation of intragastric solubility of drugs: in what medium?
Pharm Res. 2007 May;24(5):909-17. doi: 10.1007/s11095-006-9209-9. Epub 2007 Mar 20.
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Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs.
Nat Rev Drug Discov. 2007 Mar;6(3):231-48. doi: 10.1038/nrd2197.
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Simulation of fasting gastric conditions and its importance for the in vivo dissolution of lipophilic compounds.
Eur J Pharm Biopharm. 2005 Aug;60(3):413-7. doi: 10.1016/j.ejpb.2005.03.002.
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Effect of liquid volume and food intake on the absolute bioavailability of danazol, a poorly soluble drug.
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Influence of high fat diet (butter) on pharmacokinetics of phenytoin and carbamazepine.
Methods Find Exp Clin Pharmacol. 2004 Oct;26(8):634-8. doi: 10.1358/mf.2004.26.8.863730.

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